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Result of AGM

27th Apr 2010 16:15

Results of the Annual General Meeting held on April 27, 2010

April 27, 2010 - Shire plc , the global specialty biopharmaceutical company (the "Company") announces that at its Annual General Meeting today, all resolutions contained in the notice of meeting were duly passed and the results of the poll are as follows:

Total Voting Rights at meeting date: 562,110,523 Number of votes per share: one

For* Against Withheld** 1. To receive the 412,292,765 99.36% 2,280,158 0.55% 389,618 Company's accounts together with the Directors' and Auditors' reports 2. To approve the 384,956,423 92.77% 25,721,306 6.20% 4,284,812 Directors' remuneration report 3. To elect Mr 413,524,413 99.65% 1,207,610 0.29% 230,518 David Stout as a Director of the Company 4. To elect Mr 412,613,028 99.43% 2,119,119 0.51% 230,394 William Burns as a Director of the Company 5. To re-appoint 414,444,760 99.88% 312,094 0.08% 205,687 Deloitte LLP as Auditors of the Company 6. To authorize 413,445,721 99.64% 61,212 0.01% 1,455,608 the Audit, Compliance & Risk Committee to determine the remuneration of the Auditors 7. To give 324,820,624 78.28% 76,696,659 18.48% 13,445,258 limited authority to allot shares up to a specific amount 8. To approve the 398,649,522 96.07% 10,185,457 2.45% 6,127,562 proposed amendments to the Shire Portfolio Share Plan 9. To give 414,279,932 99.84% 403,373 0.10% 279,236 authority to allot a limited number of shares for cash free of pre-emption rights 10. To give 413,924,071 99.75% 800,122 0.19% 238,348 limited authority for the purchase of its own shares by the Company

* These figures include discretionary votes

** A vote "withheld" is not a vote in law and is not counted in the calculation of the votes "for" or "against" a resolution.

Two copies of all resolutions passed, other than resolutions concerning ordinary business, will shortly be submitted to the UK Listing Authority and will be available for inspection at the UK Listing Authority's Document Viewing Facility, which is situated at the Financial Services Authority, 25 The North Colonnade, Canary Wharf, London E14 5HS.

For further information please contact:

Investor Relations Cl©a Rosenfeld (Rest of the World) +44 1256 894 160 Eric Rojas (North America) +1 617 551 9715 Media Jessica Mann (Rest of the World) +44 1256 894 280 Matthew Cabrey (North America) +1 484 595 8248 Jessica Cotrone (North America) +1 617 613 4640 Notes to editorsSHIRE PLC

Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit hyperactivity disorder (ADHD), human genetic therapies (HGT) and gastrointestinal (GI) diseases as well as opportunities in other therapeutic areas to the extent they arise through acquisitions. Shire's in-licensing, merger and acquisition efforts are focused on products in specialist markets with strong intellectual property protection and global rights. Shire believes that a carefully selected and balanced portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

For further information on Shire, please visit the Company's website: www.shire.com.

2Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PXPress Release

www.shire.com

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