Re Agreement with Pfizer

Cyprotex announces a collaborative research agreement with Pfizer

30 October 2012 - Cyprotex PLC (AIM:CRX), the preclinical ADME-Tox services company, today announces a collaborative research agreement between Apredica LLC (a wholly owned subsidiary of Cyprotex PLC) and Pfizer Inc. The deal extends over an eighteen month period and is split into two stages with the second stage being dependent on certain milestones being achieved. The collaboration is a research-based project which the parties aim to evaluate, further develop, and improve several of Cyprotex's proprietary offerings in the area of predictive toxicology.

Dr. Anthony Baxter, Cyprotex's Chief Executive Officer, comments on the collaboration: "We are delighted to be able to continue our relationship with Pfizer. This collaborative research is beneficial for both companies and allows Cyprotex to remain at the forefront of new approaches in toxicology prediction. Predicting drug-induced toxicity is a challenging field, and we are making significant advances by combining our knowledge with that of our partners and clients."

For further information:

Notes to Editors

About Cyprotex PLC

Cyprotex is based in Macclesfield, near Manchester in the UK, and Watertown, Boston in the US and is listed on the AIM market of the London Stock Exchange (CRX). The company was established in 1999 and works with more than 700 partners ranging from small biotechs to large pharma companies. Cyprotex acquired Apredica and the assets of Cellumen Inc. in August 2010 and the combined business provides support for a wide range of experimental and computational ADME-Tox and PK services, extending from early drug discovery through to IND submission. The company's core capabilities include high quality in vitro ADME screening services, mechanistic toxicology and high content toxicology screening services and predictive modelling using PBPK and QSAR techniques, including Cloe® PK for in vivo PK prediction. For more information, see www.cyprotex.com.