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Purchase of Shares by Employee Benefit Trust

18th Aug 2006 17:13

18 August 2006Shire plc ("Shire")Purchase of Shares by Employee Benefit TrustShire has been notified that on 17 August 2006, the Shire plc Employee BenefitTrust (the "Trust") purchased 140,000 Ordinary Shares of Shire plc ("Shares")at an average price of 869.3656 pence per Share. This purchase was madepursuant to the Trustee's irrevocable, non-discretionary programme to purchaseShares during the period commencing 16th August 2006 to 30th September 2006.All of the employees of Shire plc and its subsidiaries, including the ExecutiveDirectors and persons exercising managerial responsibility, are potentialbeneficiaries of the Trust. The Executive Directors and persons exercisingmanagerial responsibility over Shire are therefore deemed to have an interestin the Shares held by the Trust.For further information please contact:Investor Relations Clĩa Rosenfeld (Rest of the World) +44 1256 894 160 Brian Piper (North America) +1 484 595 8252 Notes to editorsSHIRE PLCShire's strategic goal is to become the leading specialty pharmaceuticalcompany that focuses on meeting the needs of the specialist physician. Shirefocuses its business on attention deficit and hyperactivity disorder (ADHD),human genetic therapies (HGT), gastrointestinal (GI) and renal diseases. Thestructure is sufficiently flexible to allow Shire to target new therapeuticareas to the extent opportunities arise through acquisitions. Shire believesthat a carefully selected portfolio of products with a strategically alignedand relatively small-scale sales force will deliver strong results.Shire's focused strategy is to develop and market products for specialtyphysicians. Shire's in-licensing, merger and acquisition efforts are focused onproducts in niche markets with strong intellectual property protection eitherin the US or Europe.For further information on Shire, please visit the Company's website: www.shire.com. Hampshire International Business Park Chineham Basingstoke Hampshire RG24 8EP United Kingdom Tel +44 (0)1256 894000 Fax +44 (0)1256 894708 www.shire.com Press Release Registered in England 2883758 Registered Office as aboveENDSHIRE PLC

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