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Purchase of Shares by Employee Benefit Trust

30th Dec 2005 10:00

30 December 2005Shire plc ("Shire")Purchase of Shares by Employee Benefit TrustShire has been notified that on 29 December 2005, the Shire plc EmployeeBenefit Trust (the "Trust") purchased 85,000 Ordinary Shares of Shire plc("Shares") at an average price of 747.1113 pence per Share. This purchase wasmade pursuant to the Trustee's irrevocable, non-discretionary programme topurchase Shares during the period commencing on 23rd December 2005 and endingon 23rd February 2006.All of the employees of Shire plc and its subsidiaries, including the ExecutiveDirectors and persons exercising managerial responsibility, are potentialbeneficiaries of the Trust. The Executive Directors and persons exercisingmanagerial responsibility over Shire are therefore deemed to have an interestin the Shares held by the Trust.For further information please contact:Investor Relations Clĩa Rosenfeld (Rest of the World) +44 1256 894 160 Brian Piper (North America) +1 484 595 8252 Notes to editorsSHIRE PLCShire's strategic goal is to become the leading specialty pharmaceuticalcompany that focuses on meeting the needs of the specialist physician. Shirefocuses its business on central nervous system (CNS), gastrointestinal (GI),general products (GP) and human genetic therapies (HGT) - all being areas inwhich Shire has a commercial presence. The structure is sufficiently flexibleto allow Shire to target new therapeutic areas to the extent opportunitiesarise through acquisitions. Shire believes that a carefully selected portfolioof products with a strategically aligned and relatively small-scale sales forcewill deliver strong results. Shire's focused strategy is to develop and marketproducts for specialty physicians. This approach aims to deliver increasedreturns and lower risks. Shire's in-licensing and merger and acquisitionefforts are focused on products in niche markets with strong intellectualproperty protection either in the US or Europe.For further information on Shire, please visit the Company's website: www.shire.com. Hampshire International Business Park Chineham Basingstoke Hampshire RG24 8EP United Kingdom Tel +44 (0)1256 894000 Fax +44 (0)1256 894708 www.shire.com Press Release Registered in England 2883758 Registered Office as aboveENDSHIRE PLC

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