Publication of Supplementary Reg Doc & Prospectus

NatWest Markets Plc

Publication of Supplementary Registration Document and Supplementary Prospectus

Each of the following supplementary registration document and supplementary prospectus has been approved by the Financial Conduct Authority and is available for viewing:

Supplementary Registration Document to the NatWest Markets Plc Registration Document, dated 3 December 2021.

Supplementary Prospectus to the NatWest Markets Plc US$10,000,000,000 US Medium-Term Note Programme, dated 3 December 2021.

To view the full documents, please paste the following URLs into the address bar of your browser:

http://www.rns-pdf.londonstockexchange.com/rns/5730U_1-2021-12-3.pdf

http://www.rns-pdf.londonstockexchange.com/rns/5730U_2-2021-12-3.pdf

A copy of each of the above supplementary registration document and supplementary prospectus has been submitted to the National Storage Mechanism and will shortly be available for inspection at:

https://data.fca.org.uk/#/nsm/nationalstoragemechanism

For further information, please contact:

Mark Anwender

NatWest Treasury DCM, Head of Documentation and Funding

Tel: +44 (0) 7385 366 760

DISCLAIMER - INTENDED ADDRESSEES

Please note that the information contained in the Prospectus may be addressed to and/or targeted at persons who are residents of particular countries (specified in each of the Prospectus) only and is not intended for use and should not be relied upon by any person outside of these countries and/or to whom the offer contained in the Prospectus is not addressed. Prior to relying on the information contained in the Prospectus you must ascertain from the Prospectus whether or not you are part of the intended addressees of the information contained therein.

Your right to access this service is conditional upon complying with the above requirement.

Legal Entity Identifier:

NatWest Markets Plc - RR3QWICWWIPCS8A4S074