Publication of Supplementary Prospectus - EMTN

SANTANDER UK PLC - PUBLICATION OF SUPPLEMENTAL PROSPECTUS

The following Prospectus has been approved by the UK Listing Authority and is available for viewing:

Supplemental Prospectus dated 08 November 2010 relating to the U.S.$20,000,000,000 Euro Medium Term Note Programme of Abbey National Treasury Services plc as Issuer of Senior Notes guaranteed by Santander UK plc and Santander UK plc as Issuer of Subordinated Notes.

To view the full Supplemental Prospectus, please paste the following URL into the address bar of your browser:

http://www.rns-pdf.londonstockexchange.com/rns/8316V_-2010-11-8.pdf

The full Supplemental Prospectus is also available for viewing at the National Storage Mechanism. This website is not provided for, or directed at, U.S. persons or persons in the United States. If you are a U.S. person or are viewing this page from the United States, you should exit this section of the website.

For further information, please contact:

Debt Capital Markets

Tel: +44 (0) 20 7756 7100 or [email protected]

DISCLAIMER - INTENDED ADDRESSEES

Please note that the information contained in the Supplemental Prospectus may be addressed to and/or targeted at persons who are residents of particular countries (specified in the Prospectus) only and is not intended for use and should not be relied upon by any person outside these countries and/or to whom the offer contained in the Prospectus is not addressed. Prior to relying on the information contained in the Prospectus, you must ascertain from the Prospectus whether or not you are part of the intended addressees of the information contained therein.

Your right to access this service is conditional upon complying with the above requirement.

The Supplemental Prospectus on this website does not constitute an offer of securities for sale in the United States. The securities described herein have not been, and will not be, registered under the U.S. Securities Act of 1933, as amended (the 'Securities Act'), or under any relevant securities laws of any state of the United States of America, and may not be offered or sold to U.S. persons or to persons within the United States of America, except pursuant to an exemption from the Securities Act.

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