Publication of Offering Circular

3rd May 2007 13:40

Publication of Offering Circular

The following Offering Circular has been approved by the UK Listing Authority and is available for viewing:

Offering Circular dated 3 May 2007, relating to U.S. $1,000,000,000 fixed rate bonds (subject to an increase of up to a further U.S. $100,000,000) to be issued by Shire plc, convertible into ordinary shares in Shire plc.

To view the full document, please paste the following URL into the address bar of your browser:

http://www.shire.com/shire/pdfs/OfferingCircularProspectusMay2007.pdf

For further information please contact:

Investor Relations Clĩa Rosenfeld (Rest of the World) +44 1256 894 160

Media Jessica Mann (Rest of the World) +44 1256 894 280

DISCLAIMER - INTENDED ADDRESSEES

Please note that the information contained in the Offering Circular may be addressed to and/or targeted at persons who are residents of particular countries (specified in the Offering Circular) only and is not intended for use and should not be relied upon by any person outside these countries and/or to whom the offer contained in the Offering Circular is not addressed. Prior to relying on the information contained in the Offering Circular you must ascertain from the Offering Circular whether or not you are part of the intended addressees of the information contained therein.

Persons accessing this service acknowledge and agree that the information contained herein is made available pursuant to the requirements of the UK Listing Authority and is not for publication or distribution, directly or indirectly, in or into the United States or to any U.S. person. The materials do not constitute an offer of securities for sale in the United States. These securities have not been and will not be registered under the Securities Act of 1933 and are subject to U.S. tax law requirements. Accordingly, these securities may not be offered, sold or delivered in the United States or to U.S. persons. There is no intention to register any portion of the offering in the United States or to conduct an offering of securities in the United States.

Your right to access this service is conditional upon complying with the above requirements.

2Hampshire International Business Park Chineham Basingstoke Hampshire RG24 8EP United Kingdom Tel +44 (0)1256 894000 Fax +44 (0)1256 894708 www.shire.com Press Release

Registered in England 5492592Registered Office as above

SHIRE PLC

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