PUBLICATION OF NOTICE OF GENERAL MEETING

PUBLICATION OF NOTICE OF GENERAL MEETING

London, 20 March 2018 - Mereo BioPharma Group plc (AIM: MPH) (the "Company"), a multi-asset biopharmaceutical company focused on rare and specialty diseases, confirms that an explanatory circular (the "Circular"), which incorporates a notice convening a general meeting (the "Notice of General Meeting"), and a form of proxy will be posted to shareholders today.

The general meeting is to be held at the offices of Latham & Watkins (London) LLP, 99 Bishopsgate, London EC2M 3XF at 12.00 pm (noon) (London time) on 6 April 2018 and is being held in order for shareholders to vote on the adoption of new articles of association of the Company (the "New Articles").

A copy of the Circular (incorporating the Notice of General Meeting) is available on the Company's website at www.mereobiopharma.com/investors-page/regulatory-news/.

The New Articles and the current articles of association (and a comparison of changes to the current articles of association) are also available for inspection on the Company's website at www.mereobiopharma.com/investors-page/aim-rule-26/.

FOR FURTHER ENQUIRIES:

Mereo BioPharma Group plc

+44 (0)333 023 7319

Denise Scots-Knight, Chief Executive Officer

Richard Jones, Chief Financial Officer

Nominated Adviser and Joint Broker

CantorFitzgerald Europe

+44 (0)20 7894 7000

Phil Davies

Will Goode

Joint Broker

RBC Capital Markets

+44 (0)20 7653 4000

Rupert Walford

Laura White

Public Relations Adviser to Mereo Biopharma

FTI Consulting

+44 (0)20 3727 1000

Ben Atwell

Simon Conway

Brett Pollard