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PDMR Share Dealings

1st Mar 2013 16:00

SHIRE PLC - PDMR Share Dealings

SHIRE PLC - PDMR Share Dealings

PR Newswire

London, March 1

PDMR Share Dealings

March 1, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG), (the "Company") announcesthe following dealings by Persons Discharging Managerial Responsibility ("PDMRs")n American Depository Shares ("ADSs"). One ADS is equal to three Shire plcrdinary shares of 5 pence each.

Release of Performance Share Awards ("PSA Awards")

In accordance with the rules of the Portfolio Share Plan ("PSP"), the followingADSs were released on February 28, 2013 in connection with PSA Awards grantedunder Part B of the PSP. The Company was notified today that on February 28,2013 sufficient ADSs were sold on the NASDAQ at an average sale price of$94.1859 to satisfy the related personal tax liabilities of each PDMR.

Number of ADSs Number of Date of grant released 2 ADSs sold Ann Judge1 28/02/2012 297 91 28/02/2011 423 149 Jeffrey Jonas1 28/02/2012 386 114 28/02/2011 507 152 1 The PSA Awards were granted prior to Ann Judge and Jeffrey Jonas becoming PDMRs. In accordance with the rules of the PSP, such awards vest incrementally over a three year period. 2 In accordance with the rules of the PSP, the vested PSA awards have been increased to reflect the dividends paid by the Company in the period from the grant date to the vesting date.

This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a) of theDisclosure and Transparency Rules.

Tony GuthrieDeputy Company Secretary

For further information please contact:

Investor RelationsEric Rojas [email protected] +1 781 482 0999Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS

Shire enables people with life-altering conditions to lead better lives.

Through our deep understanding of patients' needs, we develop and providehealthcare in the areas of:

- Behavioral Health and Gastro Intestinal conditions

- Rare Diseases

- Regenerative Medicine

as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value forpatients, physicians, policymakers, payors and our shareholders.

www.shire.com


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