PDMR DEALING - PURCHASE OF SHARES

1

Details of the person discharging managerial responsibilities/person closely associated

a)

Name

Robert Lyne

Sharon Barber-Lui

John LaMattina

Michele Holcomb

2

Reason for the notification

a)

Position/status

Robert Lyne - Interim Chief Executive Officer

Sharon Barber-Lui - Interim Board Chair; Non-Executive Director

John LaMattina - Non-Executive Director

Michele Holcomb - Non-Executive Director

b)

Initial notification/Amendment

Initial notification

3

Details of the issuer, emission allowance market participant, auction platform, auctioneer or auction monitor

a)

Name

PureTech Health plc

b)

LEI

213800LVPDNO2Z9T9I39

4

Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted

a)

Description of the financial instrument, type of instrument

Identification code

ISIN GB00BY2Z0H74

b)

Nature of the transaction

Purchase of shares in market

c)

Price(s) and volume(s)

d)

Aggregated information

e)

Date of the transaction

22-23 September 2025

f)

Place of the transaction

London Stock Exchange (XLON)