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Notification of Shares

31st Oct 2007 15:00

Alizyme PLC31 October 2007 For Immediate Release 31 October 2007 ALIZYME PLC TR - 1: NOTIFICATION OF MAJOR INTERESTS IN SHARES 1. Identity of the issuer or the underlying issuer of existingshares to which voting rights are attached: Alizyme plc 2. Reason for the notification (please tick the appropriate box or boxes): An acquisition or disposal of voting rights 3. Full name of person(s) subject to the notification obligation: The Royal Bank of Scotland Group plc 4. Full name of shareholder(s) (if different from 3.) ABN AMRO Bank N.V. 5. Date of the transaction and date on which the threshold is crossed orreached: 26/10/2007 6. Date on which issuer notified: 31/10/2007 7. Threshold(s) that is/are crossed or reached: 3% 8. Notified details: A: Voting rights attached to shares Class/type of Situation previous to Resulting situation after the triggering transactionshares the Triggering transactionif possibleusing the ISIN Number of Number of Number of Number of voting % of votingCODE Shares Voting shares rights rights Rights Direct Direct Indirect Direct IndirectOrdinaryShares 9,350,000 9,350,000 9,350,000 9,350,000 4.67%GB 2pGB0000374289 B: Financial Instruments Resulting situation after the triggering transactionType of Expiration Exercise/ Number of voting rights that may % offinancial date Conversion be acquired if the instrument is votinginstrument exercised/ converted. rights Period/ Date Total (A+B) Number of voting rights % of voting rights9,350,000 4.67% 9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable: The Royal Bank of Scotland Group plc (4.67%)RFS Holdings N.V. (4.67%)ABN AMRO Holding N.V. (4.67%)ABN AMRO Bank N.V. (4.67%) Proxy Voting: 10. Name of the proxy holder: n/a 11. Number of voting rights proxy holder will cease to hold: n/a 12. Date on which proxy holder will cease to hold voting rights: n/a 13. Additional information: This Notification has been made following the acquisition of ABN AMRO HoldingN.V. by RFS Holdings N.V. 14. Contact name: David Campbell, Finance Director 15. Contact telephone number: + 44 (0) 1223 896000 For further information, please contact: David Campbell, Finance DirectorALIZYME plc Tel No: + 44(0) 1223 896000 Further information on Alizyme can be found on the Company's website:www.alizyme.com This information is provided by RNS The company news service from the London Stock Exchange

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