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Notification of major interests in shares

30th Jul 2008 17:49

Notification of major interests in shares

Basingstoke, UK and Philadelphia, US - July 30, 2008 - Shire Limited , the global specialty biopharmaceutical company

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Shire Limited

2. Reason for the notification State Yes/No An acquisition or disposal of voting rights

An acquisition or disposal of financial instruments which Yes may result in the acquisition of shares already issued to

which voting rights are attached An event changing the breakdown of voting rights Other (please specify): New Exemption DTR 5.1.3 (4) & DTR 5.1.5 (1)

3. Full name of person(s) subject to the notification ExcellerateHRO Share obligation:

Plan Services (Guernsey) Limited 4. Full name of shareholder(s) (if different from 3.): 5. Date of the transaction (and date on which the 13 May 2008 threshold is crossed or reached if different): 6. Date on which issuer notified: 30 July 2008 7. Threshold(s) that is/are crossed or reached: 3% 8. Notified details:

A: Voting rights attached to shares

Class/type of Situation previous Resulting situation after the triggering shares to transaction if possible the Triggering using the ISIN transaction CODE Number Number Number Number of voting % of voting of of of rights rights Shares Voting shares Rights Direct Direct Indirect Direct Indirect JE00B2QKY057 Below 3% 8,524,960 8,524,960 1.52% ADRs Below 3% 2,791,605 8,374,815 1.50% B: Financial Instruments

Resulting situation after the triggering transaction

Type of Expiration Exercise/ Number of voting % of financial date Conversion rights that may be voting instrument Period/ Date acquired if the rights instrument is exercised/converted Total (A+B) Number of voting rights % of voting rights 16,899,775 3.02%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable:

ExcellerateHRO act as trustees of the Shire Employee Benefit Trust and the holdings when the threshold was exceeded was as follows:

Shares Held By Registered in the name of

No of consolidated Shares Held

Statestreet Nominees Ltd ExcellerateHRO SPS (Gsy) Ltd 1,917,710 Equiniti Registrars ExcellerateHRO SPS (Gsy) Ltd 39,250 Morgan Stanley ExcellerateHRO SPS (Gsy) Ltd 6,568,000 Morgan Stanley ExcellerateHRO SPS (Gsy) Ltd 3,910,500 JP Morgan ExcellerateHRO SPS (Gsy) Ltd 4,464,315

Total Shares held by ExcellerateHRO Guernsey Ltd as at 13th May 2008 16.899,775

Proxy Voting:10. Name of the proxy holder: N/A

11. Number of voting rights proxy holder will cease to hold: N/A 12. Date on which proxy holder will cease to hold voting N/A

rights: 13. Additional information: 14. Contact name: Emma Holland

15. Contact telephone number: 01481 726088

Contact at Shire Limited: Tony Guthrie, Deputy Company Secretary, 01256 894746

For further information please contact:

Investor Relations Clĩa Rosenfeld (Rest of the World) +44 1256 894 160 Eric Rojas (North America) +1 484 595 8252 Notes to editorsSHIRE LIMITED

Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit and hyperactivity disorder (ADHD), human genetic therapies (HGT), gastrointestinal (GI) and renal diseases. The structure is sufficiently flexible to allow Shire to target new therapeutic areas to the extent opportunities arise through acquisitions. Shire's in-licensing, merger and acquisition efforts are focused on products in niche markets with strong intellectual property protection either in the US or Europe. Shire believes that a carefully selected portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

For further information on Shire, please visit the Company's website: www.shire.com.

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

vendor

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