Notification of major interests in shares

Notification of major interests in shares November 14, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) 1. Identity of the issuer or the underlying issuer of existing shares to Shirewhich voting rights are attached: plc 2. Reason for the notification State Yes/ No An acquisition or disposal of voting rights Yes An acquisition or disposal of qualifying financial instruments which mayresult in the acquisition of shares already issued to which voting rightsare attached No An acquisition or disposal of instruments with similar economic effect toqualifying financial instruments Yes An event changing the breakdown of voting rights No Other (please specify): No 3. Full name of person(s) subject to the notification BlackRock Inc.obligation: 4. Full name of shareholder(s) (if different from 3.): N/A 5. Date of the transaction (and date on which the threshold is 12 Novembercrossed 2013or reached if different): 6. Date on which issuer notified: 13 November 2013 7. Threshold(s) that is/are crossed or reached: Above 10% 8. Notified details: A: Voting rights attached to shares Situation previous to Resulting situation after the triggering the Triggering transaction Class/type of transaction shares if possible Number Number Number Number of voting % of voting using the ISIN of of of rights rights CODE Shares Voting shares Rights Direct Direct Indirect Direct Indirect JE00B2QKY057 54,247,601 54,247,601 N/A N/A 54,081,440 N/A 9.76% B: Qualifying Financial Instruments Resulting situation after the triggering transaction Type of Expiration Exercise/ Number of voting % of financial date Conversion rights that may be voting instrument Period/ Date acquired if the rights instrument is exercised/converted N/A N/A N/A N/A N/A C: Financial Instruments with similar economic effect to Qualifying FinancialInstruments Resulting situation after the triggering transaction Type of Exercise Expiration Exercise/ Number of % of votingfinancial price date Conversion voting rightsinstrument period rights instrument refers to Nominal Delta CFD N/A N/A N/A 1,403,310 0.25% 0.25% Total (A+B+C) Number of voting rights % of voting rights 55,484,750 10.02% 9. Chain of controlled undertakings through which the voting rights and/orthe financial instruments are effectively held, if applicable: BlackRock Investment Management (UK) Limited - 55,484,750 (10.02%) Proxy Voting: 10. Name of the proxy holder: N/A 11. Number of voting rights proxy holder will cease to hold: N/A 12. Date on which proxy holder will cease to hold voting rights: N/A 13. Additional information: BlackRock Regulatory Threshold Reporting Team 14. Contact name: Duncan Murray 15. Contact telephone number: 020 7743 3334 Contact at Shire plc: Tony Guthrie, Deputy Company Secretary, 01256 894746 For further information please contact: Investor Relations Eric Rojas [email protected] +1 781 482 0999 Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,Internal Medicine and Regenerative Medicine and we are developing treatmentsfor symptomatic conditions treated by specialist physicians in other targetedtherapeutic areas.

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