Notification of major interests in shares

6th Nov 2012 16:00

Notification of major interests in shares

November 6, 2012 - Shire plc

1. Identity of the issuer or the underlying issuer of existing shares to Shire which voting rights are attached:

plc 2. Reason for the notification State Yes/ No An acquisition or disposal of voting rights Yes

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

No

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

Yes An event changing the breakdown of voting rights No

Other (please specify): No

3. Full name of person(s) subject to the notification BlackRock Inc

obligation:

4. Full name of shareholder(s) (if different from 3.): N/A

5. Date of the transaction (and date on which the threshold is 2 November crossed

2012 or reached if different): 6. Date on which issuer notified: 6 November 2012 7. Threshold(s) that is/are crossed or reached: Above 10%

8. Notified details:

A: Voting rights attached to shares Situation previous to Resulting situation after the triggering the Triggering transaction Class/type of transaction shares if possible Number Number Number Number of voting % of voting using the ISIN of of of rights rights CODE Shares Voting shares Rights Direct Indirect Direct Indirect

JE00B2QKY057 33,336,203 33,336,203 N/A N/A 54,260,621 N/A 9.66%

B: Qualifying Financial Instruments Resulting situation after the triggering transaction Type of Expiration Exercise/ Number of voting % of financial date Conversion rights that may be voting instrument Period/ Date acquired if the rights instrument is exercised/converted

: Financial Instruments with similar economic effect to Qualifying Financial Instruments

Resulting situation after the triggering transaction Type of Exercise Expiration Exercise/ Number of % of voting financial price date Conversion voting rights instrument period rights instrument refers to Nominal Delta CFD 2,272,938 0.40% 0.40% Total (A+B+C) Number of voting rights % of voting rights 56,533,559 10.06

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable:

BlackRock Investment Management (UK) Limited - 56,533,559 (10.06%) Proxy Voting: 10. Name of the proxy holder: N/A 11. Number of voting rights proxy holder will cease to hold: N/A

12. Date on which proxy holder will cease to hold voting rights: N/A

13. Additional information: BlackRock Regulatory Threshold Reporting Team 14. Contact name: Wayne Powell

15. Contact telephone number: 020 7743 2216; [email protected]

Contact at Shire plc: Tony Guthrie, Deputy Company Secretary, 01256 894746

For further information please contact:

Investor Relations Eric Rojas [email protected] +1 781 482 0999 Sarah Elton-Farr [email protected] +44 1256 894157 Notes to editors

Shire enables people with life-altering conditions to lead better lives.

Through our deep understanding of patients' needs, we develop and provide healthcare in the areas of:

Behavioral Health and Gastro Intestinal conditions

Rare DiseasesRegenerative Medicine

as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for patients, physicians, policymakers, payors and our shareholders.

XLON

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