Notification of major interests in shares

Notification of major interests in shares August 5, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) 1. Identity of the issuer or the underlying issuer of existing shares to Shirewhich voting rights are attached: plc 2. Reason for the notification State Yes/ No An acquisition or disposal of voting rights Yes An acquisition or disposal of qualifying financial instruments which mayresult in the acquisition of shares already issued to which voting rightsare attached No An acquisition or disposal of instruments with similar economic effect toqualifying financial instruments No An event changing the breakdown of voting rights No Other (please specify): No 3. Full name of person(s) subject to the notification Legal & General Groupobligation: Plc (L&G) 4. Full name of shareholder(s) (if different from 3.): N/A 5. Date of the transaction (and date on which the 01 August 2013threshold is crossedor reached if different): 6. Date on which issuer notified: 02 August 2013 7. Threshold(s) that is/are crossed or reached: L&G (Below 3%) 8. Notified details: A: Voting rights attached to shares Situation Resulting situation after the previous to triggering Class/type of shares the Triggering transaction if possible using the transaction ISIN CODE Number Number Number Number of % of voting of of of voting rights Shares Voting shares rights Rights Direct Indirect Direct Indirect JE00B2QKY057 22,269,735 Below 3% (As on 14/10/ 2009) B: Qualifying Financial Instruments Resulting situation after the triggering transaction Type of Expiration Exercise/ Number of voting % of financial date Conversion rights that may be voting instrument Period/ Date acquired if the rights instrument is exercised/converted N/A N/A N/A N/A N/A C: Financial Instruments with similar economic effect to Qualifying FinancialInstruments Resulting situation after the triggering transaction Type of Exercise Expiration Exercise/ Number of % of votingfinancial price date Conversion voting rightsinstrument period rights instrument refers to Nominal Delta N/A N/A N/A N/A N/A N/A N/A Total (A+B+C) Number of voting rights % of voting rights Below 3% Below 3% 9. Chain of controlled undertakings through which the voting rights and/orthe financial instruments are effectively held, if applicable: Legal & General Group Plc (Direct and Indirect) (Group) Legal & General Investment Management (Holdings) Limited (LGIMH)(Direct and Indirect) Legal & General Investment Management Limited (Indirect) (LGIM) Legal & General Group Plc (Direct) (L&G) (Below 3% = LGAS, LGPL & PMC) Legal & General Investment Management (Holdings) Legal & GeneralLimited (Direct) (LGIMHD) Insurance Holdings Limited (Direct) (LGIH) Legal & General Assurance (Pensions Management) Legal & GeneralLimited (PMC) Assurance Society Limited (LGAS & LGPL) Legal & General Pensions Limited (Direct) (LGPL) Proxy Voting: 10. Name of the proxy holder: N/A 11. Number of voting rights proxy holder will cease to hold: N/A 12. Date on which proxy holder will cease to hold voting rights: N/A 13. Additional Notification using the total voting rights figure ofinformation: 553,280,952 14. Contact name: Angela Hayter (LGIM) 15. Contact telephone 020 3124 3851number: Contact at Shire plc: Tony Guthrie, Deputy Company Secretary, 01256 894746 For further information please contact: Investor Relations Eric Rojas [email protected] +1 781 482 0999 Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,Internal Medicine and Regenerative Medicine and we are developing treatmentsfor symptomatic conditions treated by specialist physicians in other targetedtherapeutic areas.

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