Notification of major interest in shares

For filings with the FSA include the annex For filings with issuer exclude the annex TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi

1. Identity of the issuer or the underlying Source BioScience plcissuer of existing shares to which voting

rights are attached: ii

2. Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights An acquisition or disposal of qualifying financial instruments which

may result in the acquisition of shares already issued to which votingrights are attached

An acquisition or disposal of instruments with similar economic effectto qualifying financial instruments

An event changing the breakdown of voting rights

Other (please Change in fund manager of Henderson Fledgling Xspecify):

Trust as announced on 1 March 2013

3. Full name of person(s) subject to Henderson Global Investorsthe notification obligation: iii

4. Full name of shareholder(s) (ifdifferent from 3.):iv 5. Date of the transaction and date 1 March 2013on which the threshold is crossed orreached: v 6. Date on which issuer notified: 13 March 2013 7. Threshold(s) that is/are crossed 10%or reached: vi, vii 8. Notified details:A: Voting rights attached to shares viii, ix Class/type of Situation previous Resulting situation aftershares to the triggering the triggering transaction transaction if possible Number Number % of votingusing Number of Number of rights xthe ISIN CODE of Voting of voting Shares Rights shares rights Direct Direct Indirect Direct Indirect xi xii ORD GBP0.2 25,892,401 25,892,401 12,076,025 5.89% GB0009739649 B: Qualifying Financial Instruments Resulting situation after the triggering transaction

Type of financial Expiration Exercise/ Number of voting % of voting

instrument date xiii Conversion Period rights that may be rights xiv acquired if the instrument is exercised/ converted.

C: Financial Instruments with similar economic effect to Qualifying FinancialInstruments xv, xvi

Resulting situation after the triggering transaction Type of Exercise Expiration Exercise/ Number of voting % of voting financial price date xvii Conversion rights instrument rights xix, xx instrument period refers to xviii Nominal Delta Total (A+B+C) Number of voting rights Percentage of voting rights 12,076,025 5.89%

9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable: xxi

Proxy Voting: 10. Name of the proxy holder: 11. Number of voting rights proxyholder will cease to hold: 12. Date on which proxy holder willcease to hold voting rights: 13. Additional information: The change to the percentage of voting rights held by Henderson Global Investors relates to the change in fund manager of Henderson Fledgling Trust as announced on 1 March 2013. Going forward Henderson Fledgling Trust will notify its interest in the Company separately as announced on 8 March. 14. Contact name: Balenkosi Dungeni 15. Contact telephone number: 0207 818 3747