Notification of Major Interest in Shares

TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARES

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Alliance Pharma plc

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

√

An event changing the breakdown of voting rights

Other (please specify):

Change in nature: Shares loaned out.

√

3. Full name of person(s) subject to thenotification obligation:

Aviva plc & its subsidiaries

4. Full name of shareholder(s)  (if different from 3.):

Registered Holder:

BNY Norwich Union Nominees Limited  2,377,360*

Chase (GA Group) Nominees Limited  17,925,913*

*denotes direct interest

Chase Nominees Limited 730,258

5. Date of the transaction and date onwhich the threshold is crossed orreached:

04 December 2015

6. Date on which issuer notified:

07 December 2015

7. Threshold(s) that is/are crossed orreached:

8% to 7% Change at Direct Interest Level

8. Notified details:

A: Voting rights attached to shares

Class/type ofshares

if possible usingthe ISIN CODE

Situation previousto the triggeringtransaction

Resulting situation after the triggering transaction

NumberofShares

NumberofVotingRights

Numberof shares

Number of votingrights

% of voting rights

Direct

Direct

Indirect

Direct

Indirect

Ordinary SharesGB0031030819

24,085,876

24,085,876

21,033,531

20,303,273

730,258

7.68%

0.27%

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financialinstrument

Expirationdate

Exercise/Conversion Period

Number of votingrights that may beacquired if theinstrument isexercised/ converted.

% of votingrights

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments xv, xvi

Resulting situation after the triggering transaction

Type of financialinstrument

Exercise price

Expiration date

Exercise/Conversion period

Number of voting rights instrument refers to

% of voting rights

RIGHT TO RECALL LOANED SHARES

N/A

N/A

N/A

1,500,000*

*Direct Interest

Nominal

Delta

0.57%

Total (A+B+C)

Number of voting rights

Percentage of voting rights

22,533,531

8.52%

9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable

The voting rights are managed and controlled by Aviva Investors Global Services Limited, with the following chain of controlled undertakings:-

Aviva Investors Global Services Limited:

· Aviva plc (Parent Company)

· Aviva Group Holdings Limited (wholly owned subsidiary of Aviva plc)

· Aviva Investors Holdings Limited (wholly owned subsidiary of Aviva Group Holdings Limited)

· Aviva Investors Global Services Limited (wholly owned subsidiary of Aviva Investors Holdings Limited)

Proxy Voting:

10. Name of the proxy holder:

See Section 4

11. Number of voting rights proxy holder will ceaseto hold:

12. Date on which proxy holder will cease to holdvoting rights:

13. Additional information:

Figures are based on a total number of voting rights of 264,520,610 as per the Company's Exercise of Share Options Announcement of 21 August 2015.

14. Contact name:

Neil Whittaker, Aviva plc

15. Contact telephone number:

01603 684420