Notification of Major Interest in Shares

For immediate release

9 August 2011

1. Identity of the issuer or the underlying issuerof existing shares to which voting rights areattached:

Alliance Pharma plc

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

Yes

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

n/a

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

n/a

An event changing the breakdown of voting rights

n/a

Other (please specify):

On market transfer between direct and indirect funds

n/a

3. Full name of person(s) subject to thenotification obligation:

Royal Bank of Canada

4. Full name of shareholder(s)  (if different from 3.):

Roy Nominees Limited

5. Date of the transaction and date onwhich the threshold is crossed orreached:

03 August 2011

6. Date on which issuer notified:

05 August 2011

7. Threshold(s) that is/are crossed orreached:

10%

8. Notified details:

A: Voting rights attached to shares

Class/type ofshares

if possible usingthe ISIN CODE

Situation previousto the triggeringtransaction

Resulting situation after the triggering transaction

NumberofShares

NumberofVotingRights

Numberof shares

Number of votingrights

% of voting rights

Direct

Direct

Indirect

Direct

Indirect

Ordinary GBP 0.01 shares

ISIN

GB0031030819

23,001,088

23,001,088

24,001,088

24,001,088

10%

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financialinstrument

Expirationdate

Exercise/Conversion Period

Number of votingrights that may beacquired if theinstrument isexercised/ converted.

% of votingrights

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financialinstrument

Exercise price

Expiration date

Exercise/Conversion period

Number of voting rights instrument refers to

% of voting rights

Nominal

Delta

Total (A+B+C)

Number of voting rights

Percentage of voting rights

24,001,088

10%

9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable:

The shares are held in the name Roy Nominees Limited for the benefit of trusts administered by RBC Trustees (CI) Limited and RBC cees Trustee Limited which are wholly owned by its ultimate parent, Royal Bank of Canada.

Proxy Voting:

10. Name of the proxy holder:

11. Number of voting rights proxy holder will ceaseto hold:

12. Date on which proxy holder will cease to holdvoting rights:

13. Additional information:

14. Contact name:

Scott Roberts

15. Contact telephone number:

01534 602971