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Notice of Results

20th Apr 2011 12:00

First quarter 2011 results date notification - April 28, 2011

Dublin, Ireland - April 20, 2011 - Shire plc , the global specialty biopharmaceutical company, will announce first quarter 2011 earnings on Thursday April 28, 2011.

Results press release will be 11:00 BST / 06:00 EDT issued at: Investor conference call time: 13:00 BST / 08:00 EDT

Live conference call for investors:

Angus Russell, Chief Executive Officer and Graham Hetherington, Chief Financial Officer will host the investor and analyst conference call at 13:00 BST/8:00 EDT.

The details of the conference call are as follows:

UK dial in: 0800 077 8492 or 0844 335 0351 US dial in: 1 866 8048688 or 1 718 3541175 International dial in: +44 844 335 0351

Password/Conf ID: 172 136 Live Webcast: http://www.shire.com/shireplc/en/investors Replay:

A replay of the presentation will be available for two weeks by phone and by webcast for one year. Details can be found on our Investor Relations website http://www.shire.com/shireplc/en/investors.

For further information please contact:

Investor Relations Souheil Salah [email protected] +44 1256 894 160 Erin K. Kelly [email protected] +1 781 482 9541 Notes to editorsSHIRE PLC

Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit hyperactivity disorder (ADHD), human genetic therapies (HGT) and gastrointestinal (GI) diseases as well as opportunities in other therapeutic areas to the extent they arise through acquisitions. Shire's in-licensing, merger and acquisition efforts are focused on products in specialist markets with strong intellectual property protection and global rights. Shire believes that a carefully selected and balanced portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

For further information on Shire, please visit the Company's website: www.shire.com.

2Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PXPress Release

www.shire.com

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