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Notice of Results

15th Oct 2012 15:00

Third quarter 2012 results date notification - October 25, 2012

Dublin, Ireland - October 15, 2012 - Shire plc , will announce third quarter 2012 earnings on Thursday October 25, 2012.

Results press release will be 12:00 BST / 07:00 EDT issued at: Investor conference call time: 13:00 BST / 08:00 EDT

Live conference call for investors:

Angus Russell, Chief Executive Officer and Graham Hetherington, Chief Financial Officer will host the investor and analyst conference call at 13:00 BST/8:00 EDT.

The details of the conference call are as follows:

UK dial in: 08082370030 US dial in: 1866 928 7517 or 1 718 873 9077 International dial in: +44 2031394830

Password/Conf ID: 99054603# Live Webcast: http://www.shire.com/shireplc/en/investors Replay:

A replay of the presentation will be available for two weeks by phone and by webcast for three months. Details can be found on our Investor Relations website http://www.shire.com/shireplc/en/investors.

For further information please contact:

Investor Relations Souheil Salah [email protected] +44 1256 894 160 Erin K. Kelly [email protected] +1 781 482 9541 Notes to editors

Shire enables people with life-altering conditions to lead better lives.

Through our deep understanding of patients' needs, we develop and provide healthcare in the areas of:

* Behavioral Health and Gastro Intestinal conditions * Rare Diseases * Regenerative Medicine

as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for patients, physicians, policymakers, payors and our shareholders.

For further information on Shire, please visit the Company's website: www.shire.com.

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PXPress Release

www.shire.com

XLON

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