Notice of Optional Redemption

Issued: 14 April 2022

NOTE: THIS NOTICE CONTAINS IMPORTANT INFORMATION THAT IS OF INTEREST TO THE REGISTERED HOLDERS AND BENEFICIAL OWNERS OF THE NOTES. IF APPLICABLE, ALL DEPOSITORIES, CUSTODIANS, AND OTHER INTERMEDIARIES RECEIVING THIS NOTICE ARE REQUESTED TO EXPEDITE RE-TRANSMITTAL TO THE REGISTERED HOLDERS AND BENEFICIAL OWNERS OF THE NOTES IN A TIMELY MANNER.

The Notes were issued pursuant to an indenture dated as of April 6, 2004 among GlaxoSmithKline Capital plc, a public limited company incorporated and registered in England and Wales, as issuer (the "Issuer"), GlaxoSmithKline plc, a public limited company incorporated and registered in England and Wales, as guarantor (the "Guarantor") and Deutsche Bank Trust Company Americas as trustee (as successor to Law Debenture Trust Company of New York, pursuant to an Instrument of Resignation, Appointment and Acceptance dated April 12, 2017, among the Issuer, Law Debenture Trust Company of New York and Deutsche Bank Trust Company Americas, the "Trustee") (the "Base Indenture" and, as amended and supplemented by a first supplemental indenture, dated as of March 21, 2014 and as further amended and supplemented by a second supplemental indenture dated as of May 15, 2018, the "Indenture"). Capitalized terms used and not defined herein have the meanings ascribed to them in the Indenture or, if not defined therein, the Notes.

NOTICE IS HEREBY GIVEN that, pursuant to Section 3.02 of the Indenture, the Issuer has elected to redeem and will redeem on May 1, 2022 (the "Redemption Date") all of the remaining principal amount of the Notes outstanding at an amount equal to 100% of the principal amount of the Notes plus accrued and unpaid interest thereon to, but excluding, the Redemption Date (the "Redemption Price").

Holders of the Notes will be paid the Redemption Price upon presentation and surrender of their Notes for redemption at the following addresses:

Upon receipt of funds for such purpose from the Issuer, the Trustee shall pay, in immediately available funds, the Redemption Price of such Notes to the registered Holder of all Notes outstanding, Cede & Co., the nominee for The Depository Trust Company ("DTC"), in accordance with applicable DTC procedures.

On the Redemption Date, (i) the Redemption Price will become due and payable on the Notes, (ii) unless the Company defaults in making payment of the Redemption Price, interest on the Notes shall cease to accrue on and after the Redemption Date and (iii) the only remaining right of the holder with respect to the Notes will be to receive payment of the Redemption Price upon surrender to the Trustee. Pursuant to the terms of the Indenture, as the Redemption Date is not a Business Day, the Issuer will pay the Redemption Price for the Notes on the next succeeding Business Day, Tuesday May 3, 2022. However, interest on the payment of the Redemption Price shall not accrue during the period from the scheduled Redemption Date and Tuesday May 3, 2022.

*No representation is made as to the correctness of the CUSIP or ISIN number either as printed on the Notes or as contained in this Notice of Redemption and the holder should rely only on the other identification numbers printed on the Notes. This CUSIP number has been assigned to this issue by Standard and Poor's Corporation and is included solely for the convenience of the holders. Neither the Issuer, the Trustee nor the Paying Agent or any of their agents shall be responsible for the selection or use of this CUSIP number, nor is any representation made as to its correctness on the bonds or as indicated in any redemption notice.

IMPORTANT TAX INFORMATION

EXISTING FEDERAL INCOME TAX LAW MAY REQUIRE BACKUP WITHHOLDING OF 24% OF ANY PAYMENTS TO HOLDERS PRESENTING THEIR SECURITIES FOR PAYMENTS WHO HAVE FAILED TO FURNISH A TAXPAYER IDENTIFICATION NUMBER, CERTIFIED TO BE CORRECT UNDER PENALTY OF PERJURY ON A COMPLETE AND VALID INTERNAL REVENUE SERVICE ("IRS") FORM W-9 OR APPLICABLE FORM W-8 TO THE APPLICABLE PAYER OR WITHHOLDING AGENT. HOLDERS MAY ALSO BE SUBJECT TO A PENALTY OF $50.00 FOR FAILURE TO PROVIDE SUCH NUMBER.

Sincerely,

GLAXOSMITHKLINE CAPITAL PLC

By: Deutsche Bank Trust Company Americas, as Trustee