Notice of AGM

Banco Santander, S.A. (the "Bank" or "Banco Santander"), in compliance with the Securities Market legislation, hereby communicates the following:

OTHER RELEVANT INFORMATION

In accordance with the provisions of the Spanish Companies Law, Santander hereby attaches the full text of the notice of call to the ordinary general shareholders' meeting of the Bank to be held at Centro de Formación El Solaruco (Ciudad Grupo Santander), Avenida de Cantabria s/n, Boadilla del Monte, on 31 March 2022 at 1:00 p.m. (CEST), on first call, or on 1 April 2022, at the same place and time, on second call.

http://www.rns-pdf.londonstockexchange.com/rns/9365C_1-2022-2-25.pdf

The proposed resolutions, the required reports on the items of the agenda and the remaining documentation relating to the meeting are available on the corporate website (www.santander.com).

Boadilla del Monte (Madrid), 25 February 2022