Non Executive Director Appointment

Non Executive Director Appointment Dublin, Ireland - 23 October 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG),announces that Dominic Blakemore will join its Board of Directors effective 1January 2014 as non executive director and member of the Audit, Compliance &Risk Committee. Dominic is Group Finance Director of Compass Group PLC. Prior to this he wasChief Financial Officer at Iglo Foods Group and Finance & Strategy Director ofCadbury plc. He spent his earlier career years at PwC (PricewaterhouseCoopers),where his work included advising pharmaceutical sector clients. Matthew Emmens, Chairman of Shire commented: "The Shire Board will benefit from Dominic's strategic and financialexperience. We look forward to him joining the Board." Dominic Blakemore added: "Shire has an excellent track record of growth and a clear strategy. I lookforward to playing a part in this growing company's future." There is no further information that is required to be disclosed under 9.6.13Rof the UK Listing Rules. For further information please contact: Investor Relations Eric Rojas [email protected] +1 781 482 0999 Sarah Elton-Farr [email protected] +44 1256 894157 Media Jessica Mann [email protected] +44 1256 894 280 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,Internal Medicine and Regenerative Medicine and we are developing treatmentsfor symptomatic conditions treated by specialist physicians in other targetedtherapeutic areas. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com