New Data on Iclaprim

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Motif Bio plc

("Motif Bio" or the "Company")

New data on iclaprim released at IDWeek 2016

Iclaprim shown to be highly potent against SSSI and HABP clinical isolates

Motif Bio plc (AIM: MTFB), the clinical stage biopharmaceutical company specialising in developing novel antibiotics, announces that new data were presented on the antimicrobial activity of its lead antibiotic, iclaprim, against recent clinical samples of Gram-positive bacteria, including multidrug resistant isolates, gathered from around the World.

The new data were presented during IDWeek 2016 in New Orleans and provided details of a global in vitro microbiological surveillance programme testing 1636 strains of bacteria associated with Hospital Associated Bacterial Pneumonia ("HABP") and Skin and Skin Structure Infections ("SSSI") collected from patients in the United States, Europe, Latin America and the Asia Pacific. These bacteria were tested against iclaprim and a range of other standard of care antibiotics.

As demonstrated in the Table below, the results showed that iclaprim was highly potent against strains of Staphylococcus aureus, beta-hemolytic streptococci, and Streptococcus pneumoniae associated with clinical SSSI and HABP isolates taken globally during 2012 to 2014.

The full poster can be down loaded at:

https://idsa.confex.com/idsa/2016/webprogram/Paper56742.html

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About Motif Bio

Motif Bio is a clinical-stage biopharmaceutical company, engaged in the research and development of novel antibiotics designed to be effective against serious and life-threatening infections in hospitalized patients caused by multi-drug resistant bacteria. Our lead product candidate, iclaprim, is being developed for the treatment of acute bacterial skin and skin structure infections (ABSSSI) and hospital acquired bacterial pneumonia (HABP), including ventilator associated bacterial pneumonia (VABP), which is often caused by MRSA (methicillin resistant Staphylococcus aureus). We are currently enrolling and dosing patients in two global Phase 3 clinical trials (Revive 1 and Revive 2) with an intravenous formulation of iclaprim, for the treatment of ABSSSI. Patient enrolment for REVIVE-1 has exceeded projections and data readout is now expected in the second quarter of 2017, rather than the second half of 2017, as previously stated. REVIVE-2 remains on track with data readout continuing to be expected in the second half of 2017.