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Major Interest in Shares

17th Dec 2007 10:53

Alizyme PLC17 December 2007 For Immediate Release 17 December 2007 ALIZYME PLC TR - 1: NOTIFICATION OF MAJOR INTERESTS IN SHARES 1. dentity of the issuer or the underlying issuer of existingshares to which voting rights are attached: Alizyme plc 2. Reason for the notification (please tick the appropriate box or boxes): A acquisition or disposal of voting rights 3. Full name of person(s) subject to the notification obligation: Prudential plc group of companies 4. Full name of shareholder(s) (if different from 3.) See attached schedule 5. Date of the transaction and date on which the threshold is crossed orreached: 12 December 2007 6. Date on which issuer notified: 14 December 2007 7. Threshold(s) that is/are crossed or reached: See item 13 8. Notified details: A: Voting rights attached to shares Class/type Situation previous to the Resulting situation after the triggering transactionof shares Triggering transactionif possibleusing the Number of Number of Number of Number of voting % of votingISIN CODE Shares Voting Rights shares rights rights Direct Direct Indirect Direct IndirectOrdinary 29,750,419 29,750,419 29,850,419 29,850,419 14.8%SharesGB 2pGB0000374289 B: Financial Instruments Resulting situation after the triggering transactionType of Expiration Exercise/ Number of voting rights that may be % offinancial date Conversion acquired if the instrument is votinginstrument exercised/ converted. rights Period/ Daten/a n/a n/a n/a n/a Total (A+B) Number of voting rights % of voting rights 29,850,419 14.8% 9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable Prudential plc (parent Company) M&G Group Limited (wholly owned subsidiary of Prudential plc) M&G Limited (wholly owned subsidiary of M&G Group Limited) M&G Investment Management Limited (wholly owned subsidiary of M&G Limited) M&G Securities Limited (wholly owned subsidiary of M&G Limited) The Prudential Assurance Company Limited (wholly owned subsidiary of Prudentialplc) Proxy Voting: 10. Name of the proxy holder: n/a 11. Number of voting rights proxy holder will cease to hold: n/a 12. Date on which proxy holder will cease to hold voting rights: n/a 13. Additional information As per 5.1.2, the non-exempt holdings for Prudential plc have crossed 3%triggering this notification. 14. Contact name: David Campbell, Finance Director 15. Contact telephone number: + 44 (0) 1223 896000 For further information, please contact: David Campbell, Finance DirectorALIZYME plc Tel No: + 44 (0) 1223 896000 Further information on Alizyme can be found on the Company's website: www.alizyme.com This information is provided by RNS The company news service from the London Stock Exchange

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Prudential
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