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Major Interest in Shares

6th Feb 2007 17:53

Alizyme PLC06 February 2007 For Immediate Release 6 February 2007 ALIZYME PLC TR - 1: NOTIFICATION OF MAJOR INTERESTS IN SHARES 1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached : Alizyme Plc 2. Reason for the notification (please tick the appropriate box or boxes): An acquisition or disposal of voting rights (No)An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached(No)An event changing the breakdown of voting rights (No) 3. Full name of person(s) subject to the notification obligation : Legal & General Group Plc (L&G) 4. Full name of shareholder(s) (if different from 3.) n/a 5. Date of the transaction and date on which the threshold is crossed or reached n/a 6. Date on which issuer notified: 02/02/2007 7. Threshold(s) that is/are crossed or reached: Above 3% (L&G) 8. Notified details: A: Voting rights attached to shares Class/ Situation previous Resulting situation after the triggeringtype of to the Triggering transactionshares transactionifpossible Number Number of Number of Number of voting % of votingusing of Voting shares rights rightsthe ISIN Shares RightsCODE Direct Direct Indirect Direct Indirect Ord GBP 4,760,048 3.29% 7,317,003 7,317,003 3.66% 0.02 (under S-198 on 06/04/2004) B: Financial Instruments Resulting situation after the triggering transaction xiiType of Expiration Exercise/ Number of voting rights that may % offinancial date xiii Conversion be acquired if the instrument is votinginstrument Period/ Date exercised/ converted. rights xiv n/a n/a n/a n/a n/a Total (A+B) Number of voting rights % of voting rights 7,317,003 3.66% Proxy Voting: 10. Name of the proxy holder: n/a 11. Number of voting rights proxy holder will cease to hold: n/a 12. Date on which proxy holder will cease to hold voting rights: n/a9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable 13. Additional information Legal & General Group Plc (Direct andIndirect) (Group) Legal & General Investment Management(Holdings) Limited (LGIMH) (Direct andIndirect) Legal & General Investment Management Limited(Indirect) (LGIM) Legal & General Group Plc (Direct) (L&G) (7,317,003-3.66% = LGAS, LGPL & PMC) Legal & General Investment Management Legal & General Insurance Holdings(Holdings) Limited (Direct) Limited (Direct) (LGAS & LGPL) Legal & General Assurance (Pensions Legal & General Assurance SocietyManagement) Limited (PMC) Limited (LGAS & LGPL) Legal & General Pensions Limited (Direct) (LGPL) Notification using shares in issue figure of 199,683,517 First notification under DTR Sourcebook 14. Contact name: David Campbell, Finance Director 15. Contact telephone number: + 44 (0) 1223 896000 For further information, please contact: David Campbell, Finance DirectorALIZYME plc Tel No: + 44 (0) 1223 896000 Further information on Alizyme can be found on the Company's website:www.alizyme.com This information is provided by RNS The company news service from the London Stock Exchange

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