Joint Service Offering

Cyprotex and InSphero announce launch of new 3D microtissue service

6 September, 2012 - Cyprotex PLC (LSE: CRX), the specialist preclinical contract research organisation (CRO), and InSphero AG, experts in three dimensional microtissue research, announce a joint service offering which combines the expertise of both companies to provide customers with advanced cellular models of drug-induced toxicity in the liver.

The new liver toxicology screening service will use InSphero's 3D InSightTM liver model and will be performed at Cyprotex's laboratories, where customers will have the benefit of Cyprotex's extensive expertise in ADME and toxicology. The liver model has the advantage that the cells are viable for a longer time period and so multiple dose studies can be performed over an extended time course.

Hepatotoxicity (liver toxicity) is one of the most common reasons for drug withdrawal through drug-induced toxicity. Conventional preclinical toxicology studies fail to predict human hepatotoxicity in approximately 50% of cases. This has led to an urgent need for human cell-based in vitro models which are representative of the native organ.

The current industry approach is to use cells in a single layer culture (known as a 2D monolayer). There have been recent significant advances in the field of three-dimensional (3D) cellular models and InSphero has invented a unique high throughput approach to generating 3D microtissues from single cells. InSphero's microtissues have the advantage of being completely scaffold-free and do not rely on a bioartificial matrix for reformation. This leads to highly functional microtissues, which show stable enzyme activity over extended periods of time. Compared to 2D cultures, 3D microtissues more closely mimic native tissues and organs and form natural cell-to-cell attachments. Both single cell type and multiple cell type models can be produced.

Commenting on the joint offering, Dr. Anthony Baxter, the Chief Executive Officer of Cyprotex, said: "A key objective of our research is to improve the extrapolation of in vitro data to the clinical situation. 3D microtissues more closely mimic the native tissues in the body and, as such, are more predictive of the in vivo processes when compared with existing 2D models. The interest in 3D cell models is expanding rapidly, and these models are likely to impact greatly in the development of new therapies, especially in the area of oncology, and in our ability to predict drug-related toxicity in man."

Dr Jan Lichtenberg, Chief Executive Officer and Co-founder of InSphero, commented: "With Cyprotex, we have found an excellent partner to help industry take full advantage of our highly functional 3D liver microtissues. Our joint offering combines leading 3D cell-culture expertise with the proven ADME-Tox experience of a world-leading specialist. This assures high-quality data and reliable processes for our fee-for-service customers and makes advanced, predictive toxicology testing easily available to drug developers worldwide."

Visit the Cyprotex website to find out more information about this service.

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Notes to Editors

About Cyprotex PLC

Cyprotex is based in Macclesfield, near Manchester in the UK, and Watertown, Boston in the US and is listed on the AIM market of the London Stock Exchange (CRX). The company was established in 1999 and works with more than 700 partners ranging from small biotechs to large pharma companies. Cyprotex acquired Apredica and the assets of Cellumen Inc. in August 2010 and the combined business provides support for a wide range of experimental and computational ADME-Tox and PK services, extending from early drug discovery through to IND submission. The company's core capabilities include high quality in vitro ADME screening services, mechanistic toxicology and high content toxicology screening services and predictive modelling using PBPK and QSAR techniques, including Cloe® PK for in vivo PK prediction. For more information, see www.cyprotex.com.

About InSphero AG

InSphero is a leading supplier of organotypic, biological in vitro 3D microtissues for highly predictive drug testing. The company, headquartered in Zurich, Switzerland, currently counts 7 of the top ten global pharmaceutical and cosmetics companies as customers. InSphero 3D Insight™ Microtissues enable more biologically relevant in vitro applications in efficacy (e.g. in oncology) and toxicology, including long-term and inflammation-mediated toxicity. A broad portfolio of tumour and liver microtissues is available from a number of cell sources, with additional toxicology models in the pipeline. The spin-off company of the Swiss Federal Institute of Technology (ETH) Zurich and the University Zurich has been recognised for its scientific and commercial achievements with a number of national and international awards and is also certified to the ISO 9001:2008 standard for its Quality Management System. For more information, see www.insphero.com.