Jeff Poulton Appointed Shire Chief Financial Officer

Jeff Poulton Appointed Shire Chief Financial Officer and Joins Board of Directors Dublin, Ireland- April 30, 2015 - Shire plc (LSE: SHP, NASDAQ: SHPG) announcesthe appointment of Jeff Poulton as Chief Financial Officer (CFO) and member ofthe Executive Committee. Jeff will additionally join the Shire Board ofDirectors. Both appointments are effective immediately. Jeff has served as Interim CFO since December 2014, while overseeing InvestorRelations. As CFO, he will remain based in Lexington. An experiencedpharmaceuticals and biotechnology executive, Jeff has extensive experienceacross financial, commercial and strategic leadership roles. He joined Shire in2003. Shire CEO Flemming Ornskov said: "Jeff brings demonstrated leadershipcapabilities across all elements of the finance organization as well as deepknowledge of the Shire business and effective relationships with the investmentcommunity and other stakeholders. We are pleased he will continue to provideleadership as we deliver our growth plan and drive operational excellence andefficiency that will help us to become a world-leading biotech focused on theunmet needs in rare diseases and other specialty conditions." Shire Chairman of the Board of Directors Susan Kilsby commented: "Jeff willjoin the Shire Board of Directors at a time when the company is building forthe future. We have conducted an extensive search of both internal and externalcandidates. Jeff's expertise and extensive knowledge of Shire's business andmarkets set him apart as CFO and will further strengthen the Shire board as itoversees the company's transformation." Jeff's experience at Shire includes leading the Global Rare Diseases businessunit, and overseeing the integration of Viropharma's rare diseases productsinto the Shire portfolio. Previously, Jeff served in diverse corporate financeand business development roles for Cinergy Corp. and PPG Industries. Jeffserved as a commissioned officer in the United States Navy, and has a B.A. ineconomics from Duke University and a MBA in Finance from the Kelly School ofBusiness at Indiana University. For further information please contact: Investor Relations Sarah Elton-Farr [email protected] +44 1256 894157 Media Michele Galen [email protected] +1 781 482-1867 Brooke Clarke [email protected] +44 7801 457543 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We focus on providing treatments in Rare Diseases, Neuroscience,Gastrointestinal and Internal Medicine and we are developing treatments forsymptomatic conditions treated by specialist physicians in other targetedtherapeutic areas, such as Ophthalmics. www.shire.com There is no information required to be disclosed in respect of Jeff Poultonunder Listing Rules 9.6.13.R. Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com