Issue of shares to a Director Total Voting rights

Biome Technologies plc

("Biome", "the Company" or "the Group")

Issue of shares to a Director

Total Voting rights

Further to the announcement of 28 March 2013 the Company has issued 12,800,000 new ordinary shares of 0.1p each ("Ordinary Shares") to Capita Trustees Limited which will be transferred to Leapacross Ltd ("Leapacross"), a company of which John Standen is a director and the majority shareholder, pursuant to the first tranche of the consultancy agreement with Leapacross.

Application has been made to the London Stock Exchange for admission of the new Ordinary Shares and dealings are expected to occur on 29 April 2013. Following the issue of the new Ordinary Shares, the total issued share capital and total voting rights of the Company is 5,897,666,333 Ordinary Shares with voting rights. This figure may be used by shareholders in the Company as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change in their interest in, the share capital of the Company under the FCA's Disclosure and Transparency Rules.

For further information please contact: