Interim Management Statement

Vectura Group plc: Interim Management Statement

Chippenham, UK - 22 July 2011: Vectura Group plc (LSE: VEC) ("Vectura"), today holds its Annual General Meeting (AGM) and publishes its Interim Management Statement for the period from 1 April 2011 to 21 July 2011. This update summarises comments to be made by Mr Jack Cashman, Chairman, and Dr Chris Blackwell, Chief Executive Officer, at the Company's AGM, which takes place today at 11.00 am.

On 23 May 2011, Vectura reported its Final Results for the year ended 31 March 2011. Revenues increased by 7% to £42.9m and loss after tax fell by 14% to £8.8m. The Group ended the year with a strong cash position of £74.4m and trading since 1 April 2011 has been in line with the Board's expectations.

Vectura and its licensees have made good progress since the start of the financial year with the key events highlighted below:

·; NVA237 (COPD)

o Data from Novartis' pivotal Phase III GLOW1 study announced in April 2011 demonstrated that NVA237 significantly improved lung function while demonstrating a good safety profile in patients with moderate-to-severe COPD

§ NVA237 met its primary endpoint, demonstrating superior bronchodilation (trough FEV1) relative to placebo (p

o Data from Novartis' pivotal Phase III GLOW2 study announced in June 2011 demonstrated that NVA237 is superior to placebo and similar to tiotropium in improving lung function in chronic obstructive pulmonary disease (COPD)

§ NVA237 provided superior 24-hour bronchodilation to placebo (p

o Additional data from the GLOW1 study is expected at the European Respiratory Society (ERS) meeting in September 2011

o Novartis expects the first NVA237 regulatory submission by the end of 2011 and to launch the product in 2012

·; QVA149 (COPD)

o In July 2011 the US Food and Drug Administration (FDA) approved Novartis' once-daily LABA, indacaterol, at 75 mcg, for the long-term maintenance bronchodilator treatment of airflow obstruction in patients with COPD

o Novartis expect to commence the regulatory submissions of QVA149, the fixed-dose combination of NVA237 with indacaterol, in 2012, with the first product launches expected in 2013

·; VR315 (asthma/COPD), VR632 (asthma/COPD) and VR506 (asthma)

o Continued development progress

Dr Chris Blackwell, Chief Executive of Vectura:

"We have seen some significant pipeline developments since the start of this financial year. Novartis announced further positive NVA237 Phase III data and confirmed that they will file the product by the end of 2011, with an expectation of launch in 2012. In addition, we believe that FDA approval of Novartis' indacaterol, part of the fixed-dose combination that forms QVA149, is a positive development for the prospects of the product. Novartis expects the first product launches of QVA149 in 2013. With multiple short-term catalysts ahead from the clinical programmes, as well as potential licensing opportunities, Vectura looks forward to continued good progress in the second half of 2011."

- Ends -

Enquiries

Notes for editors

About Vectura

Vectura Group plc develops inhaled therapies principally for the treatment of respiratory diseases. Vectura's main products target diseases such as asthma and chronic obstructive pulmonary disease (COPD), a growing market that is currently estimated to be worth in excess of $25 billion.

Vectura has six products marketed by its partners and a portfolio of drugs in clinical and pre-clinical development, a number of which have been licensed to major pharmaceutical companies. Vectura has development collaborations and licence agreements with several pharmaceutical companies, including Novartis, Sandoz (the generics arm of Novartis), Baxter and GlaxoSmithKline (GSK).

Vectura seeks to develop certain programmes itself where this will optimise value. Vectura's formulation and inhalation technologies are available to other pharmaceutical companies on an out-licensing basis where this complements Vectura's business strategy.

For further information, please visit Vectura's website at www.vectura.com

Forward-looking statements

This press release contains forward-looking statements, including statements about the discovery, development and commercialisation of products. Various risks may cause Vectura's actual results to differ materially from those expressed or implied by the forward-looking statements, including: adverse results in clinical development programmes; failure to obtain patent protection for inventions; commercial limitations imposed by patents owned or controlled by third parties; dependence upon strategic alliance partners to develop and commercialise products and services; difficulties or delays in obtaining regulatory approvals to market products and services resulting from development efforts; the requirement for substantial funding to conduct research and development and to expand commercialisation activities; and product initiatives by competitors. As a result of these factors, prospective investors are cautioned not to rely on any forward-looking statements. We disclaim any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.