Horizon Therapeutics plc

FORM 8.3

IRISH TAKEOVER PANEL

DISCLOSURE UNDER RULE 8.3 OF THE IRISH TAKEOVER PANEL ACT, 1997,

TAKEOVER RULES, 2013

DEALINGS BY PERSONS WITH INTERESTS IN RELEVANT SECURITIES

REPRESENTING 1% OR MORE

1. KEY INFORMATION

Name of person dealing (Note 1)

Barclays PLC.

Company dealt in

HORIZON THERAPEUTICS PLC

Class of relevant security to which the

$0.001 ordinary shares

dealings being disclosed relate (Note 2)

Date of dealing

09 May 2023

2. INTERESTS AND SHORT POSITIONS

(a) Interests and short positions (following dealing) in the class of relevant security

dealt in (Note 3)

Class of relevant security : $0.001 ordinary shares

Long

Short

Number

(%)

Number

(%)

(1) Relevant securities

1,353,825

0.59%

515,295

0.23%

(2) Derivatives (other than options)

53,580

0.02%

0

0.00%

(3) Options and agreements to purchase/sell

1,532,700

0.67%

1,379,500

0.60%

TOTAL:

2,940,105

1.29%

1,894,795

0.83%

(b) Interests and short positions in relevant securities of the company,

other than the class dealt in (Note 3))

Class of relevant security :

Long

Short

Number

(%)

Number

(%)

(1) Relevant securities

(2) Derivatives (other than options)

(3) Options and agreements to purchase/sell

TOTAL:

3. DEALINGS (Note 4)

(a) Purchases and sales

Class of relevant Security

Purchase/sale

Number of relevant securities

Price per unit(Note 5)

$0.001 ordinary shares

Purchase

1

110.6500 USD

$0.001 ordinary shares

Purchase

2

111.1200 USD

$0.001 ordinary shares

Purchase

2

111.0150 USD

$0.001 ordinary shares

Purchase

2

110.7850 USD

$0.001 ordinary shares

Purchase

2

111.0100 USD

$0.001 ordinary shares

Purchase

3

110.7900 USD

$0.001 ordinary shares

Purchase

4

110.7812 USD

$0.001 ordinary shares

Purchase

5

110.9600 USD

$0.001 ordinary shares

Purchase

5

110.9700 USD

$0.001 ordinary shares

Purchase

6

110.9100 USD

$0.001 ordinary shares

Purchase

8

110.8025 USD

$0.001 ordinary shares

Purchase

11

110.9154 USD

$0.001 ordinary shares

Purchase

20

110.6430 USD

$0.001 ordinary shares

Purchase

25

110.8028 USD

$0.001 ordinary shares

Purchase

31

110.5800 USD

$0.001 ordinary shares

Purchase

52

110.8200 USD

$0.001 ordinary shares

Purchase

100

110.5400 USD

$0.001 ordinary shares

Purchase

100

110.5050 USD

$0.001 ordinary shares

Purchase

110

110.8863 USD

$0.001 ordinary shares

Purchase

125

110.8504 USD

$0.001 ordinary shares

Purchase

148

111.1432 USD

$0.001 ordinary shares

Purchase

152

111.1407 USD

$0.001 ordinary shares

Purchase

159

110.7835 USD

$0.001 ordinary shares

Purchase

171

111.1453 USD

$0.001 ordinary shares

Purchase

200

110.8450 USD

$0.001 ordinary shares

Purchase

200

110.8180 USD

$0.001 ordinary shares

Purchase

200

110.6800 USD

$0.001 ordinary shares

Purchase

210

110.8942 USD

$0.001 ordinary shares

Purchase

220

110.8409 USD

$0.001 ordinary shares

Purchase

313

110.8831 USD

$0.001 ordinary shares

Purchase

453

110.9638 USD

$0.001 ordinary shares

Purchase

600

110.8978 USD

$0.001 ordinary shares

Purchase

627

110.7225 USD

$0.001 ordinary shares

Purchase

660

110.6499 USD

$0.001 ordinary shares

Purchase

747

111.1022 USD

$0.001 ordinary shares

Purchase

1,000

110.8500 USD

$0.001 ordinary shares

Purchase

1,010

110.5114 USD

$0.001 ordinary shares

Purchase

1,097

110.5555 USD

$0.001 ordinary shares

Purchase

1,306

110.9254 USD

$0.001 ordinary shares

Purchase

1,399

110.7479 USD

$0.001 ordinary shares

Purchase

1,600

110.8118 USD

$0.001 ordinary shares

Purchase

1,848

110.8581 USD

$0.001 ordinary shares

Purchase

2,417

110.8321 USD

$0.001 ordinary shares

Purchase

2,605

110.8010 USD

$0.001 ordinary shares

Purchase

2,719

110.7635 USD

$0.001 ordinary shares

Purchase

2,741

110.8400 USD

$0.001 ordinary shares

Purchase

4,836

110.9000 USD

$0.001 ordinary shares

Purchase

5,251

110.8700 USD

$0.001 ordinary shares

Purchase

5,828

110.7431 USD

$0.001 ordinary shares

Purchase

6,386

110.9266 USD

$0.001 ordinary shares

Purchase

6,401

110.8661 USD

$0.001 ordinary shares

Purchase

6,799

110.8236 USD

$0.001 ordinary shares

Purchase

8,541

110.6650 USD

$0.001 ordinary shares

Purchase

11,046

110.9719 USD

$0.001 ordinary shares

Purchase

11,146

110.9770 USD

$0.001 ordinary shares

Purchase

12,889

110.9836 USD

$0.001 ordinary shares

Purchase

21,755

110.8858 USD

$0.001 ordinary shares

Purchase

25,993

110.9082 USD

$0.001 ordinary shares

Purchase

62,149

111.0064 USD

$0.001 ordinary shares

Purchase

67,500

110.8114 USD

$0.001 ordinary shares

Purchase

97,078

111.0000 USD

$0.001 ordinary shares

Purchase

98,195

110.9983 USD

$0.001 ordinary shares

Sale

5

110.9100 USD

$0.001 ordinary shares

Sale

19

110.7300 USD

$0.001 ordinary shares

Sale

31

110.5800 USD

$0.001 ordinary shares

Sale

95

110.7848 USD

$0.001 ordinary shares

Sale

146

110.8776 USD

$0.001 ordinary shares

Sale

200

110.8567 USD

$0.001 ordinary shares

Sale

201

110.8097 USD

$0.001 ordinary shares

Sale

268

111.0351 USD

$0.001 ordinary shares

Sale

305

110.9190 USD

$0.001 ordinary shares

Sale

400

110.9125 USD

$0.001 ordinary shares

Sale

421

111.0125 USD

$0.001 ordinary shares

Sale

549

110.9927 USD

$0.001 ordinary shares

Sale

555

110.8920 USD

$0.001 ordinary shares

Sale

604

110.8500 USD

$0.001 ordinary shares

Sale

615

110.9800 USD

$0.001 ordinary shares

Sale

653

110.9902 USD

$0.001 ordinary shares

Sale

775

110.9564 USD

$0.001 ordinary shares

Sale

798

110.9397 USD

$0.001 ordinary shares

Sale

940

111.0531 USD

$0.001 ordinary shares

Sale

1,000

110.5653 USD

$0.001 ordinary shares

Sale

1,000

110.5300 USD

$0.001 ordinary shares

Sale

1,002

110.8799 USD

$0.001 ordinary shares

Sale

1,010

110.8161 USD

$0.001 ordinary shares

Sale

1,080

110.9405 USD

$0.001 ordinary shares

Sale

1,115

111.1470 USD

$0.001 ordinary shares

Sale

1,385

110.9791 USD

$0.001 ordinary shares

Sale

1,438

110.9833 USD

$0.001 ordinary shares

Sale

1,768

111.0069 USD

$0.001 ordinary shares

Sale

2,176

110.9885 USD

$0.001 ordinary shares

Sale

2,270

110.9795 USD

$0.001 ordinary shares

Sale

2,484

110.8600 USD

$0.001 ordinary shares

Sale

2,715

111.0075 USD

$0.001 ordinary shares

Sale

2,892

110.9725 USD

$0.001 ordinary shares

Sale

2,934

110.9452 USD

$0.001 ordinary shares

Sale

3,028

110.9859 USD

$0.001 ordinary shares

Sale

3,100

110.7945 USD

$0.001 ordinary shares

Sale

3,181

110.9432 USD

$0.001 ordinary shares

Sale

5,000

110.5000 USD

$0.001 ordinary shares

Sale

5,114

110.9608 USD

$0.001 ordinary shares

Sale

5,151

110.8700 USD

$0.001 ordinary shares

Sale

5,516

110.9943 USD

$0.001 ordinary shares

Sale

6,169

110.9953 USD

$0.001 ordinary shares

Sale

7,184

110.8523 USD

$0.001 ordinary shares

Sale

7,999

110.9895 USD

$0.001 ordinary shares

Sale

8,258

110.9316 USD

$0.001 ordinary shares

Sale

11,448

111.0210 USD

$0.001 ordinary shares

Sale

11,575

111.0002 USD

$0.001 ordinary shares

Sale

14,470

110.9468 USD

$0.001 ordinary shares

Sale

16,086

110.8617 USD

$0.001 ordinary shares

Sale

18,000

110.9666 USD

$0.001 ordinary shares

Sale

18,708

110.9367 USD

$0.001 ordinary shares

Sale

19,911

111.0271 USD

$0.001 ordinary shares

Sale

25,000

110.8652 USD

$0.001 ordinary shares

Sale

55,000

110.8027 USD

$0.001 ordinary shares

Sale

68,806

110.8136 USD

$0.001 ordinary shares

Sale

118,816

111.0000 USD

(b) Derivatives transactions (other than options transactions)

Product name

Nature of transaction (Note 6)

Number of relevant securities (Note 7)

Price per unit(Note 5)

(c) Options transactions in respect of existing relevant securities

(i) Writing, selling, purchasing or varying

Class of

Product name

Writing, selling,

Number of securities

Exercise price

Type

Expiry date

Option money

relevant security

purchasing,

to which the option

paid/received

varying etc.

relates (Note 7)

per unit (Note 5)

(ii) Exercising

Product name

Number of

Exercise price per

securities

unit (Note 5)

(d) Other dealings (including transactions in respect of new securities) (Note 4)

Nature of transaction

Details

Price per unit

(Note 8)

(if applicable) (Note 5)

4. OTHER INFORMATION

Agreements, arrangements or understandings relating to options or derivatives

Full details of any agreement, arrangement or understanding between the person disclosing

and any other person relating to the voting rights of any relevant securities under any option

referred to on this form or relating to the voting rights or future acquisition or disposal of any

relevant securities to which any derivative referred to on this form is referenced. If none, this

should be stated

NONE

Is a Supplemental Form 8 attached? (Note 9)

YES

Date of disclosure:

10 May 2023

Contact name:

Large Holdings Regulatory Operations

Telephone number:

020 3134 7213

If a connected EFM, name of offeree/offeror with which connected

If a connected EFM, state nature of connection (Note 10)

SUPPLEMENTAL FORM 8

IRISH TAKEOVER PANEL

DISCLOSURE UNDER RULE 8.1 AND RULE 8.3 OF THE IRISH TAKEOVER PANEL

ACT, 1997, TAKEOVER RULES, 2007 (AS AMENDED)

DETAILS OF OPEN POSITIONS

(This form should be attached to Form 8.1(a) & (b)(i), Form 8.1(b)(ii) or Form 8.3, as appropriate)OPEN POSITIONS

Class of

Product Description

Writing, selling,

Number of securities

Exercise price

Type

Expiry date

relevant security

purchasing,

to which the option

per unit

varying etc.

relates

$0.001 ordinary shares

Put Options

Written

495,500

100.0000

American

16 Jun 2023

$0.001 ordinary shares

Put Options

Written

150,000

90.0000

American

19 May 2023

$0.001 ordinary shares

Put Options

Purchased

-65,000

95.0000

American

19 May 2023

$0.001 ordinary shares

Put Options

Purchased

-67,300

110.0000

American

19 May 2023

$0.001 ordinary shares

Put Options

Purchased

-25,000

85.0000

American

19 May 2023

$0.001 ordinary shares

Put Options

Purchased

-250,000

80.0000

American

16 Jun 2023

$0.001 ordinary shares

Put Options

Written

10,200

80.0000

American

18 Aug 2023

$0.001 ordinary shares

Put Options

Written

250,000

105.0000

American

16 Jun 2023

$0.001 ordinary shares

Put Options

Written

400,000

100.0000

American

18 Aug 2023

$0.001 ordinary shares

Put Options

Written

65,000

105.0000

American

19 May 2023

$0.001 ordinary shares

Put Options

Purchased

-800,000

80.0000

American

18 Aug 2023

$0.001 ordinary shares

Put Options

Written

162,000

105.0000

American

21 Jul 2023

$0.001 ordinary shares

Put Options

Purchased

-162,000

90.0000

American

21 Jul 2023

$0.001 ordinary shares

Put Options

Purchased

-10,200

100.0000

American

18 Aug 2023