HORIZON THERAPEUTICS PLC

FORM 8.3

IRISH TAKEOVER PANEL

DISCLOSURE UNDER RULE 8.3 OF THE IRISH TAKEOVER PANEL ACT, 1997,

TAKEOVER RULES, 2007 (AS AMENDED)

DEALINGS BY PERSONS WITH INTERESTS IN RELEVANT SECURITIES

REPRESENTING 1% OR MORE

1.

KEY INFORMATION

Name of person dealing (Note 1)

Barclays PLC.

Company dealt in

HORIZON THERAPEUTICS PLC

Class of relevant security to which the dealings being disclosed relate (Note 2)

$0.001 ordinary shares

Date of dealing

06 Jun 2023

2.

INTERESTS AND SHORT POSITIONS

(a)

Interests and short positions (following dealing) in the class of relevant security dealt in (Note 3)

Class of relevant security:

$0.001 ordinary shares

Long

Short

Number

(%)

Number

(%)

(1)

Relevant securities 

1,071,054

0.47%

676,470

0.30%

(2)

Derivatives (other than options):

140,756

0.06%

98,064

0.04%

(3)

Options and agreements to purchase/sell:

1,420,000

0.62%

936,400

0.41%

TOTAL:

2,631,810

1.15%

1,710,934

0.75%

(b)

Interests and short positions in relevant securities of the company, other than the class dealt in

Class of relevant security:

Long

Short

Number

(%)

Number

(%)

(1)

Relevant securities

(2)

Derivatives (other than options):

(3)

Options and agreements to purchase/sell:

TOTAL:

3.

DEALINGS (Note 4)

(a)

Purchase and sales

Class of relevant Security

Purchase/sale

Number of securities

Price per unit

$0.001 ordinary shares

Purchase

50

99.7500 USD

$0.001 ordinary shares

Purchase

100

99.9400 USD

$0.001 ordinary shares

Purchase

207

99.8900 USD

$0.001 ordinary shares

Purchase

211

99.9000 USD

$0.001 ordinary shares

Purchase

291

99.8635 USD

$0.001 ordinary shares

Purchase

300

99.8600 USD

$0.001 ordinary shares

Purchase

400

99.8774 USD

$0.001 ordinary shares

Purchase

400

99.8650 USD

$0.001 ordinary shares

Purchase

438

99.8445 USD

$0.001 ordinary shares

Purchase

684

99.8641 USD

$0.001 ordinary shares

Purchase

979

99.8928 USD

$0.001 ordinary shares

Purchase

1,004

99.8322 USD

$0.001 ordinary shares

Purchase

1,141

99.9040 USD

$0.001 ordinary shares

Purchase

1,473

99.8749 USD

$0.001 ordinary shares

Purchase

2,230

99.7019 USD

$0.001 ordinary shares

Purchase

7,796

99.8408 USD

$0.001 ordinary shares

Purchase

9,635

99.8500 USD

$0.001 ordinary shares

Purchase

11,734

99.8010 USD

$0.001 ordinary shares

Purchase

16,323

99.8405 USD

$0.001 ordinary shares

Purchase

25,872

99.8432 USD

$0.001 ordinary shares

Purchase

37,557

99.8443 USD

$0.001 ordinary shares

Purchase

38,338

99.8098 USD

$0.001 ordinary shares

Sale

4

99.7050 USD

$0.001 ordinary shares

Sale

7

99.9400 USD

$0.001 ordinary shares

Sale

11

99.9000 USD

$0.001 ordinary shares

Sale

33

99.6900 USD

$0.001 ordinary shares

Sale

44

99.9818 USD

$0.001 ordinary shares

Sale

50

99.9450 USD

$0.001 ordinary shares

Sale

54

99.6922 USD

$0.001 ordinary shares

Sale

96

99.7200 USD

$0.001 ordinary shares

Sale

100

99.7800 USD

$0.001 ordinary shares

Sale

103

99.8672 USD

$0.001 ordinary shares

Sale

123

99.9700 USD

$0.001 ordinary shares

Sale

300

99.6800 USD

$0.001 ordinary shares

Sale

334

99.6834 USD

$0.001 ordinary shares

Sale

399

99.9119 USD

$0.001 ordinary shares

Sale

426

99.8144 USD

$0.001 ordinary shares

Sale

433

99.8414 USD

$0.001 ordinary shares

Sale

435

99.8299 USD

$0.001 ordinary shares

Sale

500

99.8800 USD

$0.001 ordinary shares

Sale

507

99.8536 USD

$0.001 ordinary shares

Sale

537

99.9271 USD

$0.001 ordinary shares

Sale

898

99.9480 USD

$0.001 ordinary shares

Sale

1,057

99.7507 USD

$0.001 ordinary shares

Sale

1,283

99.8974 USD

$0.001 ordinary shares

Sale

1,313

99.8348 USD

$0.001 ordinary shares

Sale

1,542

99.8173 USD

$0.001 ordinary shares

Sale

1,900

99.8368 USD

$0.001 ordinary shares

Sale

2,032

99.8390 USD

$0.001 ordinary shares

Sale

2,142

99.8673 USD

$0.001 ordinary shares

Sale

2,302

99.8501 USD

$0.001 ordinary shares

Sale

5,187

99.8260 USD

$0.001 ordinary shares

Sale

6,627

99.8233 USD

$0.001 ordinary shares

Sale

7,042

99.8706 USD

$0.001 ordinary shares

Sale

11,490

99.8000 USD

$0.001 ordinary shares

Sale

28,615

99.8383 USD

$0.001 ordinary shares

Sale

37,284

99.8415 USD

$0.001 ordinary shares

Sale

41,953

99.8163 USD

(b)

Derivatives transactions (other than option transactions)

Product Name

Nature of transaction

Number of relevant securities

Price per unit

(c)

Options transactions in respect of existing securities

(i)

Writing, selling, purchasing or varying

Class of relevant security

Product description

Writing, purchasing, selling, varying etc

Number of securities to which option relates

Exercise price per unit

Type

Expiry date

Option money paid/ received per unit

$0.001 ordinary shares

Put Options

Purchasing

2,500

105.0000 USD

American

16 Jun 2023

5.9000 USD

(ii)

Exercising

Product name

Number of securities

Exercise price per unit

(d)

Other dealings (including transactions in respect of new securities) (Note 4)

Nature of transaction

Details

Price per unit (if applicable)

4.

OTHER INFORMATION

Agreements, arrangements or understandings relating to options or derivatives

Full details of any agreement, arrangement or understanding between the person disclosing and any other person relating to the voting rights of any relevant securities under any option referred to on this form or relating to the voting rights or future acquisition or disposal of any relevant securities to which any derivative referred to on this form is referenced. If none, this should be stated.

NONE

Is a Supplemental Form 8 (Open Positions) attached?

YES

Date of disclosure:

07 Jun 2023

Contact name:

Large Holdings Regulatory Operations

Telephone number:

020 3134 7213

If a connected EFM, name of offeree/offeror with which connected

If a connected EFM, state nature of connection

SUPPLEMENTAL FORM 8

IRISH TAKEOVER PANEL

DISCLOSURE UNDER RULE 8.1 AND RULE 8.3 OF THE IRISH TAKEOVER PANEL

ACT, 1997, TAKEOVER RULES, 2007 (AS AMENDED)

DETAILS OF OPEN POSITIONS

(This form should be attached to Form 8.1(a) & (b)(i), Form 8.1(b)(ii) or Form 8.3, as

appropriate)

OPEN POSITIONS

Class of relevant security

Product Description

Writing, purchasing, selling, varying etc

Number of securities to which option relates

Exercise price per unit

Type

Expiry date

$0.001 ordinary shares

Put Options

Written

495,500

100

American

16 Jun 2023

$0.001 ordinary shares

Put Options

Written

28,800

095

American

21 Jul 2023

$0.001 ordinary shares

Call Options

Written

-10,600

105

American

18 Aug 2023

$0.001 ordinary shares

Put Options

Written

2,000

085

American

21 Jul 2023

$0.001 ordinary shares

Put Options

Purchased

-250,000

080

American

16 Jun 2023

$0.001 ordinary shares

Put Options

Written

247,500

105

American

16 Jun 2023

$0.001 ordinary shares

Put Options

Written

10,200

080

American

18 Aug 2023

$0.001 ordinary shares

Call Options

Written

-2,600

100

American

18 Aug 2023

$0.001 ordinary shares

Call Options

Written

-2,000

100

American

21 Jul 2023

$0.001 ordinary shares

Put Options

Written

74,000

090

American

15 Sep 2023

$0.001 ordinary shares

Put Options

Written

400,000

100

American

18 Aug 2023

$0.001 ordinary shares

Put Options

Purchased

-544,200

080

American

18 Aug 2023

$0.001 ordinary shares

Put Options

Written

162,000

105

American

21 Jul 2023

$0.001 ordinary shares

Call Options

Written

-10,000

105

American

16 Jun 2023

$0.001 ordinary shares

Put Options

Purchased

-10,200

100

American

18 Aug 2023

$0.001 ordinary shares

Put Options

Purchased

-106,800

090

American

21 Jul 2023