Holding(s) in Company

TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARES

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

SkyePharma Plc

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

Other (please specify):

Changing calculation from nominal to delta adjusted basis due to Termination of DTR TR-1 (15).

X 

3. Full name of person(s) subject to the notification obligation:

 D. E. Shaw & Co., L.P.

D.E. Shaw & Co. (U.K.), Ltd.

4. Full name of shareholder(s) (if different from 3.):

 N/A

5. Date of the transaction and date on which the threshold is crossed or reached:

 January 1, 2010

6. Date on which issuer notified:

 January 5, 2010

7. Threshold(s) that is/are crossed or reached:

 38%

8. Notified details:

A: Voting rights attached to shares

Class/type of shares

if possible using the ISIN CODE

Situation previous to the triggering transaction

Resulting situation after the triggering transaction

Number of Shares

Number of Voting Rights

Number of shares

Number of voting rights

% of voting rights

Direct

Direct

Indirect

Direct

Indirect

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financial instrument

Expiration date

Exercise/ Conversion Period

Number of voting rights that may be acquired if the instrument is exercised/ converted.

% of voting rights

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financial instrument

Exercise price

Expiration date

Exercise/ Conversion period

Number of voting rights instrument refers to

% of voting rights

 Contract for Differences ("CfD") relating to convertible bond due 2024

 March 4, 2010

 3,885,933

Nominal

Delta

 16.23%

("CfD") relating to convertible bond due 2025

 December 3, 2010

 2,626,779

Nominal

Delta

 10.97%

("CfD") relating to convertible bond due 2025

 June 3, 2010

 2,626,779

Nominal

Delta

 10.97%

Total (A+B+C)

Number of voting rights

Percentage of voting rights

9,139,491 

 38.17%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable:

Each of D. E. Shaw & Co., L.P. ("DESCO LP") and D. E. Shaw & Co. (U.K.), Ltd. ("DESCO UK") is notifying solely in its capacity as a discretionary investment manager. As general partner of DESCO LP, D. E. Shaw & Co., Inc. ("DESCO Inc.") is a parent undertaking of DESCO LP and DESCO UK. By virtue of David E. Shaw's position as president and sole shareholder of DESCO, Inc., which is the general partner of DESCO LP, David E. Shaw is a parent undertaking of DESCO LP and DESCO UK.

Proxy Voting:

10. Name of the proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

14. Contact name:

 Stephen Back (Compliance Department)

15. Contact telephone number:

 +1 212-478-0000