Holding(s) in Company

TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARES

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Microgen PLC

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

X

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

Other (please specify):

3. Full name of person(s) subject to the notification obligation:

Highclere International Investors Ltd

4. Full name of shareholder(s) (if different from 3.):

The Highclere International Investors International Smaller Companies Fund

The Highclere (Jersey) International Investors Smaller Companies Fund

5. Date of the transaction and date on which the threshold is crossed or reached:

1st November 2010

6. Date on which issuer notified:

2nd November 2010

7. Threshold(s) that is/are crossed or reached:

Above 4%

8. Notified details:

A: Voting rights attached to shares

Class/type ofshares

if possible usingthe ISIN CODE

Situation previousto the triggeringtransaction

Resulting situation after the triggering transaction

NumberofShares

NumberofVotingRights

Numberof shares

Number of votingrights

% of voting rights

Direct

Direct

Indirect

Direct

Indirect

ORDINARY

3,093,162

3,093,162

3,234,973

3,234,973

0

4.01%

0

GB0005869531

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financialinstrument

Expirationdate

Exercise/ConversionPeriod

Number of votingrights that may beacquired if theinstrument isexercised/ converted.

% of votingrights

N/A

N/A

N/A

N/A

N/A

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financialinstrument

Exerciseprice

Expirationdate

Exercise/Conversionperiod

Number of votingrights instrumentrefers to

% of voting rights

N/A

N/A

N/A

N/A

N/A

Nominal

Delta

N/A

N/A

Total (A+B+C)

Number of voting rights

Percentage of voting rights

3,234,973

4.01%

9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable:

N/A 

Proxy Voting:

10. Name of the proxy holder:

Highclere International Investors Ltd

11. Number of voting rights proxy holder will cease to hold:

Not Applicable

12. Date on which proxy holder will cease to hold voting rights:

Not Applicable

13. Additional information:

Highclere International Investors Ltd ("Highclere") acts as an investment manager for the clients detailed in Question 4 above (our "Clients"). In acting for our Clients, Highclere are given full discretion over their investments and are empowered to vote on their behalf. However, we do not act as our Clients' custodian and therefore shares are not held in our name but in the nominee name of their custodian bank.

14. Contact name:

Fergus Gilmour, Compliance Officer

15. Contact telephone number:

0207-258-9845