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Holding(s) in Company

30th Apr 2008 15:45

Notification of major interests in shares

Basingstoke, UK and Philadelphia, US - April, 30 2008 - Shire plc

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Shire plc

2. Reason for the notification State Yes/No An acquisition or disposal of voting rights Yes An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached An event changing the breakdown of voting rights

Other (please specify): New Exemption DTR 5.1.3 (4) & DTR Yes 5.1.5 (1)

3. Full name of person(s) subject to the notification The Goldman Sachs obligation:

Group Inc 4. Full name of shareholder(s) (if different from 3.): Goldman, Sachs & Co.,

Goldman Sachs Asset Management International, Goldman Sachs Asset Management, L.P., Goldman Sachs Financial Markets, L.L.C. Goldman Sachs Execution and Clearing, L.P

5. Date of the transaction (and date on which the 25 April 2008 threshold is crossed or reached if different): 6. Date on which issuer notified: 30 April 2008 7. Threshold(s) that is/are crossed or reached: 5% 8. Notified details:

A: Voting rights attached to shares

Class/type of Situation previous to Resulting situation after the triggering

shares the Triggering transaction if possible transaction using the ISIN CODE Number Number Number Number of voting % of voting of of of rights rights Shares Voting shares Rights Direct Direct Indirect Direct Indirect GB00B0KQX869 Below 3% 14,131,540 2.526% US82481R1068 Below 3% 12,165 14,191,176 0.002% 2.537% (4,055 (4,730,392 ADRs) ADRs) B: Financial Instruments

Resulting situation after the triggering transaction

Type of Expiration Exercise/ Number of voting % of financial date Conversion rights that may be voting instrument Period/ Date acquired if the rights instrument is exercised/converted Total (A+B) Number of voting rights % of voting rights 28,334,881 5.07%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable:

The interest in 1,425,311 shares arose from an interest held by Goldman, Sachs & Co., a wholly-owned subsidiary of The Goldman Sachs Group Inc, acting as custodian for its customers. These shares are, or will be, registered in the name of Goldman Sachs Securities (Nominees), Limited.

The interest in 9,057,942 shares arose from the interest held by Goldman Sachs Asset Management International, a wholly owned subsidiary of The Goldman Sachs Group Inc acting as discretionary manager.

The interest in 3,648,287 shares arose from the interest held by Goldman Sachs Asset Management, LP a wholly owned subsidiary of The Goldman Sachs Group Inc acting as discretionary manager.

The interest in 14,126,763 shares arose from an interest held by Goldman, Sachs & Co., a wholly-owned subsidiary of The Goldman Sachs Group Inc, acting as custodian for its customers of 4,708,921 American Depositary Receipts that are, or will be, held at the Depositary Trust Company of New York.

The interest in 60,513 shares arose from an interest held by Goldman, Sachs & Co., a wholly-owned subsidiary of The Goldman Sachs Group Inc, acting as discretionary manager of 20,171 American Depositary Receipts that are, or will be, held at the Depositary Trust Company of New York.

The interest in 3,900 shares arose from the interest held by Goldman Sachs Asset Management, LP a wholly owned subsidiary of The Goldman Sachs Group Inc acting as discretionary manager of 1,300 American Depositary Receipts that are, or will be, held at the Depositary Trust Company of New York.

The interest in 11,085 shares arose from a beneficial interest held by Goldman Sachs Financial Markets L.L.C, a wholly owned indirect subsidiary of The Goldman Sachs Group Inc. of 3,695 American Depositary Receipts that are, or will be, held at the Depositary Trust Company of New York.

The interest in 1,080 shares arose from a beneficial interest held by Goldman Sachs Execution and Clearing LP, a wholly owned indirect subsidiary of The Goldman Sachs Group Inc. of 360 American Depositary Receipts that are, or will be, held at the Depositary Trust Company of New York.

Proxy Voting:10. Name of the proxy holder: N/A

11. Number of voting rights proxy holder will cease to hold: N/A 12. Date on which proxy holder will cease to hold voting N/A

rights: 13. Additional information: General Email Contact: [email protected] 14. Contact name: Sean Rogers/Alex Cox

15. Contact telephone number: 0207-552-9205 / 0207-774 -8774

Contact at Shire plc: Tony Guthrie, Deputy Company Secretary, 01256 894754

For further information please contact:

Investor Relations Clĩa Rosenfeld (Rest of the World) +44 1256 894 160 Eric Rojas (North America) +1 484 595 8252 Notes to editorsSHIRE PLC

Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit and hyperactivity disorder (ADHD), human genetic therapies (HGT), gastrointestinal (GI) and renal diseases. The structure is sufficiently flexible to allow Shire to target new therapeutic areas to the extent opportunities arise through acquisitions. Shire's in-licensing, merger and acquisition efforts are focused on products in niche markets with strong intellectual property protection either in the US or Europe. Shire believes that a carefully selected portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

For further information on Shire, please visit the Company's website: www.shire.com.

Hampshire International Business Park Chineham Basingstoke Hampshire RG24 8EP United Kingdom Tel +44 (0)1256 894000 Fax +44 (0)1256 894708 www.shire.com Press Release

Registered in England 5492592 Registered Office as above

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