Holding(s) in Company

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Alphameric Plc

2. Reason for the notification  (please tick the appropriate box or boxes)

An acquisition or disposal of voting rights 

√

An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An event changing the breakdown of voting rights

Other (please specify):___________________________________________

3. Full name of person(s) subject to the notification obligation:

Aviva plc & its subsidiaries

4. Full name of shareholder(s) (if different from 3.):

Registered holder:

BNY Norwich Union Nominees Ltd 2,593,941*

Chase GA Group Nominees Ltd 7,811,277*

Chase Nominees Ltd 974,313*

CUIM Nominee Ltd 1,575,073*

*Denotes direct interest

Vidacos Nominees Ltd 5,078,593 

5. Date of the transaction (and date on which the threshold is crossed or reached if different):

07 January 2009

6. Date on which issuer notified:

08 January 2009

7. Threshold(s) that is/are crossed or reached:

6% to 5% change at Direct interest level

8. Notified details:

A: Voting rights attached to shares

Class/type of shares 

 if possible using the ISIN CODE

Situation previous to the Triggering transaction 

Resulting situation after the triggering transaction

Number of Shares 

Number of Voting Rights

Number of shares 

Number of voting rights 

% of voting rights

Direct

Indirect 

Direct

Indirect

Ordinary 2.5p

GB0000221894

20,275,600

20,275,600

12,954,604

12,954,604

5,078,593

5.74%

2.25%

B: Financial Instruments

Resulting situation after the triggering transaction 

Type of financial instrument 

Expiration date 

Exercise/ Conversion Period/ Date  

Number of voting rights that may be acquired if the instrument is exercised/ converted. 

% of voting rights

Total (A+B)

Number of voting rights

% of voting rights

18,033,197

7.99%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable :

The voting rights are managed and controlled by Aviva Investors Global Services Limited, with the following chain of controlled undertakings:-

Aviva Investors Global Services Limited:

Aviva plc (parent company)

Aviva Group Holdings Limited (wholly owned subsidiary of Aviva plc)

Aviva Investors Holdings Limited (wholly owned subsidiary of Aviva Group Holdings Limited)

Aviva Investors Global Services Limited (wholly owned subsidiary of Aviva Investors Holdings Limited)

Proxy Voting:

10. Name of the proxy holder:

See section 4

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

Based on the company's issued share capital of 225,415,063

14. Contact name:

Lorri Warrington

15. Contact telephone number:

01483 293971