Holding(s) in Company

TR-1: Notifications of Major Interests in Shares

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Advanced Medical Solutions

2. Reason for notification (yes/no)

An acquisition or disposal of voting rights

Yes

An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached 

An event changing the breakdown of voting rights

Other (please specify):

3. Full name of person(s) subject to notification obligation:

AXA S.A. 25 Avenue Matignon, 75008 Paris and its group of companies

4. Full name of shareholder(s) (if different from 3):

5. Date of transaction (and date on which the threshold is crossed or reached if different):

18/08/2008

6. Date on which issuer notified:

19/08/2008

7. Threshold(s) that is/are crossed or reached:

13%

8: Notified Details

A: Voting rights attached to shares

Class/type of shares

If possible use ISIN code

Situation previous to the triggering transaction

Resulting situation after the triggering transaction

Number of shares

Number of voting rights

Number of shares

Number of voting rights

Percentage of voting rights

Direct

Indirect

Direct

Indirect

Ordinary 5p shares GB0004536594

18,562,968

18,562,968

415,161

415,161

18,847,807

0.29

13.15

B: Financial Instruments

Resulting situation after the triggering transaction

Type of financial instrument

Expiration date

Exercise/ conversion period/date 

No. of voting rights that may be acquired (if the instrument exercised/converted)

Percentage of voting rights

Total (A+B)

Number of voting rights

Percentage of voting rights

19,262,968

13.44%

9. Chain of controlled undertakings through which the voting rights and /or the financial instruments are effectively held, if applicable:

Name of the Company/Fund

No of shares

% of issued share cap

AXA France

Indirect

700,000

0.48826

Sun Life Pensions Management Ltd

Direct

15,161

0.01058

Sun Life Pensions Mgmt Ltd

Direct

400,000

0.27901

AXA Framlington

Indirect

10,000,000

6.97518

AXA Framlington

Indirect

5,100,000

3.55734

Framlington onshore private clients

Indirect

2,682,250

1.87092

AWF Framlington Health

Indirect

365,557

0.25498

Total Direct

Total Indirect

415,161

18,847,807

0.28958

13.14668

Total

19,262,968

13.43626

Proxy Voting:

10. Name of proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

14 Contact name:

Mary Tavener

15. Contact telephone name:

+44 (0) 1606 545509