Holding(s) in Company

1. Reason for the notification   (please tick the appropriate box or boxes)

An acquisition  voting rights 

x

An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An event changing the breakdown of voting rights

Other (please specify): CHANGE TO THE TOTAL NUMBER OF VOTING RIGHTS IN ISSUE

2. Full name of person(s) subject to the notification obligation:

Aviva plc & its subsidiaries

3. Full name of shareholder(s) (if different from 2.):

Registered Holder:

BNY Norwich Union Nominees Limited  6,741,190*

Chase GA Group Nominees Limited 18,382,959*

Chase Nominees Limited979,009*

CUIM Nominee Limited4,812,551*

Vidacos Nominees Limited70,303*

BNP Paribas - London636,429

Chase Nominees Limited 3,518,325

State Street Nominees Limited 9,577,375

Vidacos Nominees Limited 2,003,920

*denotes direct interest

4. Date of the transaction (and date on which the threshold is crossed or reached if different):

11 August 2008

5. Date on which issuer notified:

12 August 2008

6. Threshold(s) that is/are crossed or reached:

8% to 9% Change at Direct Interest level

7. Notified details:

A: Voting rights attached to shares

Class/type of shares 

if possible using the ISIN CODE

Situation previous to the Triggering transaction 

Resulting situation after the triggering transaction

Number of Shares 

Number of Voting Rights 

Number of shares 

Number of voting rights

% of voting rights

Direct

Direct

Indirect 

Direct

Indirect

Ordinary Shares

GB0007029209

46,151,488

46,151,488

30,986,012

30,986,012

15,736,049

9.06%

4.60%

B: Financial Instruments

Resulting situation after the triggering transaction 

Type of financial instrument 

Expiration date 

Exercise/ Conversion Period/ Date 

Number of voting rights that may be acquired if the instrument is exercised/ converted. 

% of voting rights

N/A

Total (A+B)

Number of voting rights

% of voting rights

46,722,061

13.66%

8. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable :

See Section 3

Proxy Voting:

9. Name of the proxy holder:

See Section 3

10. Number of voting rights proxy holder will cease to hold:

11. Date on which proxy holder will cease to hold voting rights:

12. Additional information:

Figures are based on a total number of voting rights of 342,159,034

Protherics 

Nick Staples, Director of Corporate Affairs

+44 (0) 7919 480510

Julie Vickers, Company Secretary 

+44 (0)1928 518010

Financial Dynamics - press enquiries

London: Ben Atwell, Lara Mott

+44 (0) 20 7831 3113 

New York: John Capodanno

+1 212 850 5600