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Holding(s) in Company

29th Mar 2011 13:15

Notification of major interests in shares

March 29, 2011 - Shire plc

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Shire plc 2. Reason for the notification State Yes/No An acquisition or disposal of voting rights Yes An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached An event changing the breakdown of voting rights Other (please specify):

3. Full name of person(s) subject to the notification Capital Group obligation:

International, Inc. 4. Full name of shareholder(s) (if different from 3.):

5. Date of the transaction (and date on which the 25 March 2011 threshold is crossed

or reached if different): 6. Date on which issuer notified: 28 March 2011 7. Threshold(s) that is/are crossed or reached: Below 5% 8. Notified details:

A: Voting rights attached to shares

Situation previous to Resulting situation after the triggering the Triggering transaction transaction Class/type of shares Number Number Number Number of voting % of voting if possible of of of rights rights using the ISIN Shares Voting shares CODE Rights Direct Indirect Direct Indirect Direct Indirect

Ordinary Shares 18,519,359 18,519,359 17,993,350 17,993,350 3.2003%

(JE00B2QKY057)

ADRs 3,312,656 9,937,968 3,312,331 9,936,993 1.7674%

(US82481R1068) B: Financial Instruments

Resulting situation after the triggering transaction

Type of Expiration Exercise/ Number of voting % of voting financial date Conversion rights that may be rights instrument Period/ Date acquired if the instrument is exercised/converted n/a Total (A+B) Number of voting rights % of voting rights 27,930,343 4.9678

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable:

Number of Percent of Shares Outstanding

Capital Group International, Inc. ("CGII") 27,930,343 4.968% Holdings

Holdings by CGII Management Companies and Funds: Capital Guardian Trust Company 21,373,795 3.802% Capital International Limited 2,210,141 0.393% Capital International S rl 641,100 0.114% Capital International, Inc. 3,705,307 0.659% Proxy Voting:10. Name of the proxy holder: N/A 11. Number of voting rights proxy holder will cease to N/A hold: 12. Date on which proxy holder will cease to hold voting N/A rights: 13. Additional information: Notification using the total voting rights figures of 562,231,558 14. Contact name: Gina Martinez/Vivien Tan 15. Contact telephone number: (213) 615-0469

Contact at Shire plc: Tony Guthrie, Deputy Company Secretary, +44 1256 894746

For further information please contact:

Investor Relations Eric Rojas +1 781 482 0999 Notes to editors SHIRE PLC

Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit hyperactivity disorder (ADHD), human genetic therapies (HGT) and gastrointestinal (GI) diseases as well as opportunities in other therapeutic areas to the extent they arise through acquisitions. Shire's in-licensing, merger and acquisition efforts are focused on products in specialist markets with strong intellectual property protection and global rights. Shire believes that a carefully selected and balanced portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

For further information on Shire, please visit the Company's website: www.shire.com.

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

vendor

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