Holding(s) in Company

TR1: NOTIFICATION OF MAJOR INTEREST IN SHARES

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached: ii

Provexis plc

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

X

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

Other (please specify):

3. Full name of person(s) subject to the notification obligation: iii

ANGLE plc

4. Full name of shareholder(s)  (if different from 3.):iv

ANGLE Technology Limited

Progeny bioVentures Limited

5. Date of the transaction and date on which the threshold is crossed or reached: v

30 June 2009 and 1 July 2009

6. Date on which issuer notified:

1 July 2009

7. Threshold(s) that is/are crossed or reached: vi, vii

Falls below 6%

8. Notified details:

A: Voting rights attached to shares viii, ix

Class/type of shares

Situation previous to the triggering transaction

Resulting situation after the triggering transaction

Number of Shares

Number of Voting Rights

Number of shares

Number of voting rights

% of voting rights x

Direct

Direct xi

Indirect xii

Direct

Indirect

Ordinary shares

ISIN code

GB00B0923P27

65,145,643

65,145,643

42,395,643

42,395,643

5.2%

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financial instrument

Expiration date xiii

Exercise/  Conversion Period xiv

Number of voting rights that may be acquired if the instrument is exercised/ converted.

% of voting rights

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments xv, xvi

Resulting situation after the triggering transaction

Type of financial instrument

Exercise price

Expiration date xvii

Exercise/ Conversion period xviii

Number of voting rights instrument refers to

% of voting rights xix, xx

Nominal

Delta

Total (A+B+C)

Number of voting rights

Percentage of voting rights

42,395,643

5.2%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable: xxi

The ordinary shares in Provexis plc are owned by:

ANGLE Technology Limited - in respect of 20,426,464 shares

Progeny bioVentures Limited - in respect of 21,969,179 shares 

ANGLE plc owns:

100% of ANGLE Technology Limited; and

96.5% of Progeny bioVentures Limited

Proxy Voting:

10. Name of the proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

14. Contact name:

Ian Griffiths

15. Contact telephone number:

01483 685830