Holding(s) in Company

TR-1: Notifications of Major Interests in Shares

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

ARK THERAPEUTICS GROUP PLC

2. Reason for notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

(X)

An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached 

An event changing the breakdown of voting rights

Other

3. Full name of person(s) subject to notification obligation:

Lehman Brothers International (Europe)

4. Full name of shareholder(s) (if different from 3):

N/A

5. Date of transaction (and date on which the threshold is crossed or reached if different):

12/9/08

6. Date on which issuer notified:

16/9/08

7. Threshold(s) that is/are crossed or reached:

3%

8: Notified Details

A: Voting rights attached to shares

Class/type of shares

If possible use ISIN code

Situation previous to the triggering transaction

Resulting situation after the triggering transaction

Number of shares:

Number of voting rights:

Number of Direct: shares:

Number of voting rights:

Percentage of voting rights:

Direct:

Indirect:

Direct:

Indirect:

GB0034251727

Below 3%

Below 3% 

6,279,065 6,279,065

6,279,065

N/A

3.06%

N/A

B: Financial Instruments N/A

Resulting situation after the triggering transaction

Type of financial instrument

Expiration date

Exercise/ conversion period/date 

No. of voting rights that may be acquired (if the instrument exercised/converted)

Percentage of voting rights

Total (A+B)

Number of voting rights

Percentage of voting rights

6,279,065

3.06%

9. Chain of controlled undertakings through which the voting rights and /or the financial instruments are effectively held, if applicable:

N/A

Proxy Voting:

10. Name of proxy holder:

N/A

11. Number of voting rights proxy holder will cease to hold:

N/A

12. Date on which proxy holder will cease to hold voting rights:

N/A

13. Additional information:

N/A

14 Contact name:

Tara O'Hagan

15. Contact name and telephone number as issuer:

+44 (0) 20 7102 1832

Martyn Williams Company Secretary Ark Therapeutics Group plc

020 7388 7722