Holding(s) in Company

1. Identity of the issuer or the underlying issuer

of existing shares to which voting rights are PROTEOME SCIENCES PLC

attached: ii

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

YES

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

Other (please specify):

3. Full name of person(s) subject to the VULPES LIFE SCIENCES FUND

notification obligation: iii VULPES TESTUDO FUND

4. Full name of shareholder(s)

(if different from 3.):iv

5. Date of the transaction and date on

which the threshold is crossed or 28 DECEMBER 2016

reached: v

6. Date on which issuer notified: 29 DECEMBER 2016

7. Threshold(s) that is/are crossed or

reached: vi, vii 18%

8. Notified details:

A: Voting rights attached to shares viii, ix

Class/type of

shares

if possible using the ISIN CODE

Situation previous

to the triggering transaction

Resulting situation after the triggering transaction

Number

of Shares

Number

of Voting Rights

Number

of shares

Number of voting

rights

% of  voting rights

x

Direct

Direct xi

Indirect xii

Direct

Indirect

GB0003104196

52,973,125

52,973,125

53,238,125

53,238,125

18.09%

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financial instrument

Expiration date xiii

Exercise/ Conversion Period xiv

Number of voting rights that may be acquired if the instrument is exercised/ converted.

% of voting rights

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments

xv, xvi

Resulting situation after the triggering transaction

Type of financial

instrument

Exercise

price

Expiration date xvii

Exercise/

Conversion period xviii

Number of voting rights

instrument refers to

% of voting rights xix, xx

Nomin al

Delta

Total (A+B+C)

Number of voting rights

Percentage of voting rights

53,238,125

18.09%

  Proxy Voting:

10. Name of the proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

[email protected]

14. Contact name:

Victoria Birse

15. Contact telephone number: