Holding(s) in Company

For filings with the FSA include the annex

For filings with issuer exclude the annex

TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi

1. Identity of the issuer or the underlying issuerof existing shares to which voting rights areattached: ii

Dechra Pharamceuticals Plc

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

ü

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

Other (please specify):

3. Full name of person(s) subject to thenotification obligation: iii

FMR LLC

4. Full name of shareholder(s)  (if different from 3.):iv

See attached schedule

5. Date of the transaction and date onwhich the threshold is crossed orreached: v

21 December 2011

6. Date on which issuer notified:

22 December 2011

7. Threshold(s) that is/are crossed orreached: vi, vii

5%

8. Notified details:

A: Voting rights attached to shares viii, ix

Class/type ofshares

if possible usingthe ISIN CODE

Situation previousto the triggeringtransaction

Resulting situation after the triggering transaction

NumberofShares

NumberofVotingRights

Numberof shares

Number of votingrights

% of voting rights x

Indirect

Direct xi

Indirect xii

Direct

Indirect

GB0009633180

3,169,167

3,169,167

3,355,614

3,355,614

5.04

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financialinstrument

Expirationdate xiii

Exercise/Conversion Period xiv

Number of votingrights that may beacquired if theinstrument isexercised/ converted.

% of votingrights

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments xv, xvi

Resulting situation after the triggering transaction

Type of financialinstrument

Exercise price

Expiration date xvii

Exercise/Conversion period xviii

Number of voting rights instrument refers to

% of voting rights xix, xx

Nominal

Delta

Total (A+B+C)

Number of voting rights

Percentage of voting rights

3,355,614

5.04

9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable: xxi

See attached schedule

Proxy Voting:

10. Name of the proxy holder:

FMR LLC

11. Number of voting rights proxy holder will acquire:

186,447

12. Date on which proxy holder will acquire voting rights:

21 December 2011

13. Additional information:

None

14. Contact name:

Shaheen Hussain

15. Contact telephone number:

[email protected] / 01737 837149

Note: Annex should only be submitted to the FSA not the issuer

Annex: Notification of major interests in sharesxxii

A: Identity of the persons or legal entity subject to the notification obligation

Full name

(including legal form of legal entities)

FMR LLC

Contact address

(registered office for legal entities)

82 Devonshire Street, Boston, MA, 02109 USA

Phone number & email

01737 837148

Other useful information

(at least legal representative for legal persons)

Company Secretary

B: Identity of the notifier, if applicable

Full name

FIL Investments International

Contact address

Kingswood Fields, Millfield Lane, Lower Kingswood, Tadworth, Surrey KT20 6RB

Phone number & email

01737 837148

Other useful information

(e.g. functional relationship with the person or legal entity subject to the notification obligation)

Authorised to make this filing under power of attorney

C: Additional information

None

FMR

FMR

Issuer name:

DECHRA PHARMACEUTICALS PLC

Current ownership percentage:

5.04%

Total shares held:

3,355,614

Issued share capital:

66,474,826

SHARES HELD

NOMINEE

MANAGEMENT COMPANY

FMR LLC is the parent holding company of Fidelity

704,530

BROWN BROTHERS HARRIMAN AND CO

FMRCO

Management & Research Company (FMRCO), investment

1,446,750

CITIBANK NA

FMRCO

manager for US mutual funds, FIL Management Trust

247,100

NORTHERN TRUST CO

FMRCO

Company (FMTC), Pyramis Global Advisors Trust Company

951,734

STATE STREET BANK AND TR CO

FMR

(PGATC), a US state chartered bank which acts as a trustee

5,500

STATE STREET BANK AND TR CO

FMRCO

or investment manager of various pension and trust accounts

Pyramis Global Advisors LLC (PGALLC) and

Pyramis Trust Company (PTC).