Holding(s) in Company

1. Identity of the issuer or the underlying issuerof existing shares to which voting rights areattached:

Sinclair IS Pharma plc

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

Other (please specify): (Downward crossing of a threshold - 7% by Abingworth LLP and 5% by Abingworth Bioventures V LP)

X

3. Full name of person(s) subject to thenotification obligation:

Abingworth LLP

Abingworth Bioventures V LP

Abingworth Bioequities Master Fund Limited

4. Full name of shareholder(s)  (if different from 3.):

Bank of New York (Nominees) Limited (as nominee for Abingworth Bioventures V LP)

Jefferies & Co Inc. (as nominee for Abingworth Bioequities Master Fund Limited)

5. Date of the transaction and date onwhich the threshold is crossed orreached:

2 May 2014

6. Date on which issuer notified:

6 May 2014

7. Threshold(s) that is/are crossed orreached:

Downward crossing of 7% threshold - Abingworth LLP

Downward crossing of 5% threshold - Abingworth Bioventures V LP

8. Notified details: Abingworth LLP

A: Voting rights attached to shares

Class/type ofshares

if possible usingthe ISIN CODE

Situation previousto the triggeringtransaction

Resulting situation after the triggering transaction

NumberofShares

NumberofVotingRights

Numberof shares

Number of votingrights

% of voting rights

Direct

Direct

Indirect

Direct

Indirect

Sinclair Pharma plc

GB0033856740

1p Ords

33,433,227

33,433,227

6.72%

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financialinstrument

Expirationdate

Exercise/Conversion Period

Number of votingrights that may beacquired if theinstrument isexercised/ converted.

% of votingrights

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financialinstrument

Exercise price

Expiration date

Exercise/Conversion period

Number of voting rights instrument refers to

% of voting rights

Nominal

Delta

Total (A+B+C)

Number of voting rights

Percentage of voting rights

33,433,227

6.72%

8. Notified details: Abingworth Bioventures V LP

A: Voting rights attached to shares

Class/type ofshares

if possible usingthe ISIN CODE

Situation previousto the triggeringtransaction

Resulting situation after the triggering transaction

NumberofShares

NumberofVotingRights

Numberof shares

Number of votingrights

% of voting rights

Direct

Direct

Indirect

Direct

Indirect

Sinclair Pharma plc

GB0033856740

1p Ords

22,573,542

22,573,542

4.54%

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financialinstrument

Expirationdate

Exercise/Conversion Period

Number of votingrights that may beacquired if theinstrument isexercised/ converted.

% of votingrights

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financialinstrument

Exercise price

Expiration date

Exercise/Conversion period

Number of voting rights instrument refers to

% of voting rights

Nominal

Delta

Total (A+B+C)

Number of voting rights

Percentage of voting rights

22,573,542

4.54%

9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable:

Abingworth Bioventures V LP (which holds 22,573,542 shares in the company (4.54%)) and Abingworth Bioequities Master Fund Limited (which holds 10,859,685 shares in the company (2.18%)) are both managed by Abingworth LLP.

Proxy Voting:

10. Name of the proxy holder:

11. Number of voting rights proxy holder will ceaseto hold:

12. Date on which proxy holder will cease to holdvoting rights:

13. Additional information:

14. Contact name:

John Heard

15. Contact telephone number:

0207 534 1508