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Holding(s) in Company

19th Nov 2007 11:15

Skyepharma PLC19 November 2007 TR-1: NOTIFICATION OF MAJOR INTERESTS IN SHARES 1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached: SkyePharma plc 2. Reason for the notification (please tick the appropriate box or boxes) An acquisition or disposal of voting rights x An acquisition or disposal of financial instruments which may result in theacquisition of shares already issued to which voting rights are attached An event changing the breakdown of voting rights Other (please specify):___________________________________________ 3. Full name of person(s) subject to the notification obligation: OrbiMed Advisors LLC 4. Full name of shareholder(s) (if different from 3.): Caduceus Capital Master Fund Limited Caduceus Capital II, L.P. UBS Eucalyptus Fund, L.L.C PW Eucalyptus Fund, Ltd. Summer street Life Sceinces Hedge Fund Investors LLC 5. Date of the transaction (and date on which the threshold is crossed or reached if different): November 15,2007 6. Date on which issuer notified: November 16, 2007 7. Threshold(s) that is/are crossed or reached: 3% 8. Notified details: A: Voting rights attached to sharesClass/type of Situation previous to the Resulting situation after the triggering transaction(i)shares Triggering transaction Number of Number of Number of Number of voting rights % of voting rights if possible using Shares Voting sharesthe ISIN CODE Rights Direct Direct Indirect Direct Indirect GB0008123571 24,230,000 24,230,000 30,230,000 30,230,000 3.71% B: Financial InstrumentsResulting situation after the triggering transactionType of financial Expiration date Exercise/ Conversion Number of voting rights % of votinginstrument Period/ Date that may be acquired if rights the instrument is exercised/ converted. Total (A+B)Number of voting rights % of voting rights 30,230,000 3.71% 9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable: Not Applicable Proxy Voting: 10. Name of the proxy holder: Not Applicable 11. Number of voting rights proxy holder will cease to hold: 12. Date on which proxy holder will cease to hold voting rights: 13. Additional information: Not Applicable 14. Contact name: Eric Bittelman 15. Contact telephone number: 001-212-739-6400 Annex Notification Of Major Interests In SharesA: Identity of the person or legal entity subject to the notification obligationFull name (including legal form for legal entities)Contact address (registered office for legal entities)Phone numberOther useful information (at least legal representative forlegal persons) B: Identity of the notifier, if applicableFull nameContact addressPhone numberOther useful information (e.g. functional relationship withthe person or legal entity subject to the notificationobligation) C: Additional information -------------------------- This information is provided by RNS The company news service from the London Stock Exchange

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