Holding(s) in Company

TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARES

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

BIOFUTURES INTERNATIONAL PLC

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

ü

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

Other (please specify):

3. Full name of person(s) subject to the notification obligation:

Gartmore Investment Limited

4. Full name of shareholder(s) (if different from 3.):

See attached Schedule

5. Date of the transaction and date on which the threshold is crossed or reached:

22 March 2010

6. Date on which issuer notified:

23 March 2010

7. Threshold(s) that is/are crossed or reached:

 10%

8. Notified details:

A: Voting rights attached to shares

Class/type of shares

if possible using the ISIN CODE

Situation previous to the triggering transaction

Resulting situation after the triggering transaction

Number of Shares

Number of Voting Rights

Number of shares

Number of voting rights

% of voting rights

Direct

Direct

Indirect

Direct

Indirect

ORDINARY

GB00B12B4T47

 10,975,000

10,975,000

15,934,030

-

15,934,030

-

10.548%

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financial instrument

Expiration date

Exercise/ Conversion Period

Number of voting rights that may be acquired if the instrument is exercised/ converted.

% of voting rights

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financial instrument

Exercise price

Expiration date

Exercise/ Conversion period

Number of voting rights instrument refers to

% of voting rights

Total (A+B+C)

Number of voting rights

Percentage of voting rights

15,934,030

10.548%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable:

Proxy Voting:

10. Name of the proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

 All figures are based on the Company's issued share capital of 151,060,000 as provided by Exshare

E-mail contact: [email protected]

14. Contact name:

 RDU

15. Contact telephone number:

 0207 782 2324

For further information contact:

JULIE POMEROY, FINANCE DIRECTOR, BIOFUTURES INTERNATIONAL PLC - 07747 624 199

DEREK CROWHURST, RELIGARE CAPITAL MARKETS (NOMAD) - 0207 444 0800

DANIEL BRIGGS, RELIGARE CAPITAL MARKETS (BROKER) - 0207 444 0500

Fund Managing Company

UK Registered Owner

Beneficial Owner

% of Issued Share Capital

Shares Held

Gartmore Fund Managers Limited

HSBC Global Custody Nominee UK Ltd

Gartmore Fund Managers Ltd A/C Gartmore UK & Irish Smaller Companies

4,375,000

2.896%

Gartmore Investment Limited

Nortrust Nominees Limited

Strathclyde Pension Fund

4,550,000

3.012%

Gartmore Growth Opportunities

Gartmore Growth Opportunities Plc

1,034,030

0.685%

Vidacos Nominees Ltd A/C 2303

The Alphagen Volantis Fund Limited

5,975,000

3.955%

Total

15,934,030

10.548%