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Holding(s) in Company

13th Feb 2008 15:04

Proteome Sciences PLC ("the Company") Notifiable Interest

A form TR-1 containing the following information has been received by the Company.

TR-1 notification of major interests in shares

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Proteome Sciences

2. Reason for the notification

An acquisition or disposal of voting rights

3. Full name of person(s) subject to the notification obligation:

MF Global UK Limited

4. Full name of shareholder(s) (if different from 3):

N/A

5. Date of the transaction (and date on which the threshold is crossed or reached if different):

12/02/08

6. Date on which issuer notified:

13/02/08

7. Threshold(s) that is/are crossed or reached:

28. Notified details:3.00

A: Voting rights attached to shares

Class/type Situation previous to Resulting situation after the triggering of shares Triggering transaction transaction if possible Notification required under DTR transitionalusing ISIN provision 7 CODE Number of Number of Number of Number of voting % of voting Shares Voting shares rights rights Rights Direct Direct Indirect Direct Indirect ISIN

GB0003104196 7,880,616 7,880,616 3,932,381 3,932,381 2.99%

B: Financial Instruments

Resulting situation after the triggering transaction

Type of Expiration Exercise/ Number of voting rights that may % of financial date Conversion be acquired if the instrument is voting instrument Period/ Date exercised/ converted rights N/A N/A N/A N/A N/A Total

Number of voting rights % of voting rights

3,932,381 2.99%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable:

N/A10. Name of the Proxy holder:N/A

11. Number of voting rights proxy holder will cease to hold:

N/A

12. Date on which proxy holder will cease to hold voting rights:

N/A13. Additional information:N/A14. Contact details:[email protected]

PROTEOME SCIENCES PLC

Related Shares:

Proteome
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