Holding(s) in Company

For filings with the FSA include the annex

For filings with issuer exclude the annex 

TR-1: Notifications of Major Interests in Shares

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

ARK THERAPEUTICS GROUP PLC

2. Reason for notification (yes/no)

An acquisition or disposal of voting rights

X

An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached 

An event changing the breakdown of voting rights

Other (please specify):______________

3. Full name of person(s) subject to notification obligation:

Barclays PLC

4. Full name of shareholder(s) (if different from 3):

Barclays Bank PLC Barclays Global Investors Ltd

Barclays Life Assurance Co Ltd

Barclays Stockbrokers Ltd

Gerrard Investment Management Ltd

Walbrook Trustees (Guernsey) Ltd

5. Date of transaction (and date on which the threshold is crossed or reached if different):

12 February 2009

6. Date on which issuer notified:

17 February 2009

7. Threshold(s) that is/are crossed or reached:

Below notifiable % to 5%

8: Notified Details

A: Voting rights attached to shares

Class/type of shares

If possible use ISIN code

Situation previous to the triggering transaction

Resulting situation after the triggering transaction

Number of shares

Number of voting rights

Number of shares

Number of voting rights

Percentage of voting rights

Direct

Indirect

Direct

Indirect

GB0034251727

2,823,783

2,823,783

10,678,222

10,678,222

5.16%

B: Financial Instruments

Resulting situation after the triggering transaction

Type of financial instrument

Expiration date

Exercise/ conversion period/date 

No. of voting rights that may be acquired (if the instrument exercised/converted)

Percentage of voting rights

Total (A+B)

Number of voting rights

Percentage of voting rights

10,678,222

5.16%

9. Chain of controlled undertakings through which the voting rights and /or the financial instruments are effectively held, if applicable:

Barclays Bank PLC Barclays Global Investors Ltd

Barclays Life Assurance Co Ltd

Barclays Stockbrokers Ltd

Gerrard Investment Management Ltd

Walbrook Trustees (Guernsey) Ltd

Proxy Voting:

10. Name of proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

14 Contact name:

Geoff Smith

15. Contact telephone number:

0207 116 2913

MARTYN WILLIAMS Company Secretary Ark Therapeutics Group plc

020 7388 7722