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Holding(s) in Company

4th Jun 2007 17:37

Protherics PLC04 June 2007 Protherics PLC Notification of Major Interest in Shares London, UK; Brentwood, TN, US; 4 June 2007 - Protherics PLC ("Protherics" or the"Company"), the international biopharmaceutical company focused on critical careand cancer, announces that, on 1 June 2007, a notification of interest in theordinary share capital of the Company was received from Aviva plc as follows: 1. Reason for the notification (please tick the appropriate box or boxes) An acquisition or disposal of voting rights x An acquisition or disposal of financial instruments which may result in the acquisitionof shares already issued to which voting rights are attached An event changing the breakdown of voting rights Other (please specify):___________________________________________ 2. Full name of person(s) subject to the Aviva plc & its subsidiariesnotification obligation: 3. Full name of shareholder(s) (if different from Registered Holder:2.): BNY Norwich Union Nominees Limited 6,691,145* Chase GA Group Nominees Limited 15,059,813* Chase Nominees Limited 913,209* CUIM Nominee Limited 5,394,609* Vidacos Nominees Limited 76,113* BNP Paribas - London 1,000,000 Chase Nominees Limited 841,504 CUIM Nominee Limited 3,550,079 State Street Nominees Limited 5,590,498 Vidacos Nominees Limited 1,270,150 *denotes direct interest 4. Date of the transaction (and date on which the 31 May 2007threshold is crossed or reached if different): 5. Date on which issuer notified: 1 June 2007 6. Threshold(s) that is/are crossed or reached: 7% to 8% Change at Direct Interest level 7. Notified details: A: Voting rights attached to sharesClass/type of Situation previous to Resulting situation after the triggering transactionshares the Triggering transactionif possible using Number of Number of Number of Number of voting rights % of voting rightsthe ISIN CODE Shares Voting shares Rights Direct Direct Indirect Direct Indirect Ordinary Shares 23,774,294 23,774,294 28,134,889 28,134,889 12,252,231 8.29% 3.61% (Direct) (Direct) GB0007029209 16,634,944 16,634,944 (Indirect) (Indirect) B: Financial InstrumentsResulting situation after the triggering transactionType of financial Expiration date Exercise/ Conversion Number of voting rights % of votinginstrument Period/ Date that may be acquired if rights the instrument is exercised/ converted. N/A Total (A+B)Number of voting rights % of voting rights 40,387,120 11.90% 8. Chain of controlled undertakings through which the voting rights and/or the financial instruments areeffectively held, if applicable : See Section 3 Proxy Voting:9. Name of the proxy holder: See Section 310. Number of voting rights proxy holder will cease to hold:11. Date on which proxy holder will cease to hold voting rights: 12. Additional information: Figures are based on a total number of voting rights of 339,211,977 | Ends | For further information please contact: ProthericsNick Staples, Director of Corporate Affairs +44 (0) 7919 480510Julie Vickers, Company Secretary +44 (0)1928 518010 Financial Dynamics - press enquiriesLondon: Ben Atwell, Anna Keeble +44 (0) 20 7831 3113New York: John Capodanno, Jonathan Birt +1 212 850 5600 Or visit www.protherics.com This information is provided by RNS The company news service from the London Stock Exchange

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