Holding(s) in Company

For filings with the FCA include the annex For filings with issuer exclude the annex TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi 1. Identity of the issuer or the underlying issuerof existing shares to which voting rights areattached:ii 2 Reason for the notification (please tick the appropriate box or boxes): An acquisition or disposal of voting rights V An acquisition or disposal of qualifying financial instruments which may resultin the acquisition of shares already issued to which voting rights are attached An acquisition or disposal of instruments with similar economic effect toqualifying financial instruments An event changing the breakdown of voting rights Other (please specify): 3. Full name of person(s) subject to the Vivo Ventures VI, LLCnotification obligation:iii 4. Full name of shareholder(s) Vivo Ventures fund VI, LP (if different from 3.):iv Vivo Ventures VI Affiliates Fund, LP 5. Date of the transaction and date onwhich the threshold is crossed or March 25, 2014reached: v 6. Date on which issuer notified: March 25, 2014 7. Threshold(s) that is/are crossed or 3%reached: vi, vii 8. Notified details: A: Voting rights attached to shares viii, ix Class/type Situation previous Resulting situation after the triggering transactionof to the triggeringshares transaction if possible Number Number Number Number of voting % of voting rights xusing of of of shares rightsthe ISIN Shares VotingCODE Rights Direct Direct xi Indirect xii Direct Indirect GB00B06GSH43 16,400,000 1.70% B: Qualifying Financial Instruments Resulting situation after the triggering transaction Type of financial Expiration Exercise/ Number of voting % of votinginstrument date xiii Conversion Period xiv rights that may be rights acquired if the instrument is exercised/ converted. C: Financial Instruments with similar economic effect to Qualifying FinancialInstruments xv, xvi Resulting situation after the triggering transaction Type of Exercise price Expiration Exercise/ Number of voting rights % of voting rightsfinancial date xvii Conversion period instrument refers to xix, xxinstrument xviii Nominal Delta Total (A+B+C) Number of voting rights Percentage of voting rights 16,400,000 1.70% 9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable: xxi Vivo Ventures VI, LLC is the general partner of both Vivo Ventures Fund VI, LP (VV Fund VI) and Vivo Ventures VI Affiliates Fund, LP. (Affiliates Fund VI). Accordingly, Vivo Ventures VI, LLC may be deemed to have indirect beneficial ownership of shares of the Issuer directly owned by VV Fund VI and Affiliates Fund VI. As of the date of this filing, VV Fund VI and Affiliates Fund VI beneficially own 16,280,727 and 119,273 shares of Common Stock, respectively. Proxy Voting: 10. Name of the proxy holder: 11. Number of voting rights proxy holder will ceaseto hold: 12. Date on which proxy holder will cease to holdvoting rights: 13. Additional information: 14. Contact name: 15. Contact telephone number: